نتایج جستجو برای: wilms tumor gene 1
تعداد نتایج: 3825016 فیلتر نتایج به سال:
Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population controls (P<0.0001). Each mutation segregates with Wilms tumour in the family and a second mutational event is present in available tumours. CTR9 is a key component of the ...
1. Webber BL, Parham DM, Drake LG, et al. Renal tumors in childhood. Pathol Ann Part 1992;1:191–232. 2. Murphy WM, Beckwith JB, Farrow GM. Tumors of the kidney, bladder and related urinary structures. In: Murphy WM, Beckwith JB, Farrow GM, editors. Atlas of tumor pathology, series 3, fascicle 11. Washington D.C.: Armed Forces Institute of Pathology, 1994. 3. Beckwith JB. Pediatric neoplastic di...
WAGR syndrome is an acronym for a rare constellation of congenital abnormalities including predisposition to Wilms' tumor, Aniridia, Geni tourinary malformations, and mental Retardation. These congenital de fects are associated with a constitutional deletion affecting one copy of chromosome band Ilpl3, implicating the loss of one alÃ-elefrom a number of contiguous genes in this syndrome. Predis...
We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dacti...
Other names: Nephroblastoma Note: Wilms' tumor, although generally rare, is the most common abdominal malignancy in children. Wilms' tumor cells are believed to derive from pluripotent embyronic renal precursor cells. Thus, Wilms' tumors are linked to the early development of the kidney. While most are isolated sporadic tumors, approximately 10% of cases are associated with genetic syndromes an...
BACKGROUND Approximately 10% of nephroblastomas (Wilms' tumors) carry mutations in the Wilms' tumor 1 (WT1) gene. Recently, a WT1 antibody raised against N-terminal 1-181 amino acids of human WT1 became commercially available for immunohistochemical use on paraffin-embedded tissue. The aim of this study was to investigate the diagnostic and prognostic value of WT1 N-terminal antibody in nephrob...
We applied a subtractive hybridization approach to isolate genes differentially expressed between mature kidney and Wilms' tumor. We constructed a complementary DNA library from a total mature kidney complementary DNA subtracted by an excess of mRNA from a Wilms' tumor, WAGR4, with a germline deletion of 11p13 and a somatic loss of alleles at 11p15. Six clones presenting a differential pattern ...
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