Objective: The Rifampicin resistance and susceptibility of Mycobacterium tuberculosis are caused by mutations in the 81-base pair region of the rpoB gene encoding the b-subunit of RNA polymerase. Methods: Isoniazid resistance of M. tuberculosis is related to mutations in inha , oxyR and ahpC genes which 30 to 90 percent of Isoniazid resistance is occurred in 3015 codons of kat...

i was born in 1936 in Berlin, germany. i attended the collège Français Berlin, a historical school where all the classes are taught in French. although living in east Berlin, i studied medicine at the Free university of Berlin, located in west Berlin, from which i graduated in 1961. in 1959, i started working on my doctoral thesis, which i defended in 1962, at the institute of hygiene of the un...

Medical testing laboratories are an essential link in the efficient management of infectious diseases by identification pathogens involved. However, arrangements for their operation may appear more difficult times health crises and raise multiple issues that compromise usual level quality assurance biological analyses response to needs. The smooth running control laboratory activities a crisis ...

Cell culture technique has been used for detection and confirmation of many different viruses in clinical samples. Although, new diagnostic methods have been developed for viral infections, traditional cell culturetechnique is still regarded as the “gold standard” for several infectious agents such as human cytomegalovirus(HCMV). In the present study, a new human fetal foreskin fibr...

At present, there are only occasional cases of human plague reported in the United States. As an example, there were only 14 nonfatal cases of human plague recorded in 1988 and 5 cases in 1990. Each resulted from exposure to wild rodents, carrying the plague bacillus and fleas, in the western United States: Colorado, New Mexico, California, Arizona, and Texas. The affected individuals were trea...