The thumb was completely torn away on the palmar surface, so much so that the joint was freely exposed. The parts were much lacerated and bruised, and the extent of the wound was five inches. No bleeding of any c'onsequence occurred. The case was one for removal of the thumb, but the difficulty was how to form a flap, owing to the shape and extent of the wound. Eight sutures were put in, and co...

This article provides an overview of the mechanism of ballistic injuries. It also explores the management of patients with gunshot wounds in the emergency department.

OBJECTIVES To determine whether criminals go to the hospital when they are shot. Such information is needed to check on the accuracy of using hospital emergency room data to estimate non-fatal gunshot wounds. SETTING Five jails across the US. METHODS A survey of inmates being booked into jail, administered by in-house health care staff. RESULTS Over 90% of over 300 criminals who had been ...

After severe injury, adult mammalian wound healing occurs by formation of fibrotic scar and loss skin appendages resulting in permanent functional impairment. In mice, injuries exhibit partial regeneration, including new hair follicles (HFs) the center wound, whereas periphery remains fibrotic. We previously showed that fibroblasts residing within regenerative zone activation unique transcripti...

The role of isothiocyanate (ITC) in blocking epithelial restitution after injury and in the recovery of round wounds was examined in the ex vivo guinea pig stomach and in rat gastric mucosal-1 (RGM1) cells, respectively. For this, recovery of transepithelial electrical resistance and morphology after injury or the closure of round wounds was evaluated in the presence of 4,4'-diisothiocyanatosti...

Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Trinkaus-Randall V. Hypoxia-induced changes in Ca mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol Cell Physiol 306: C972–C985, 2014. First published March 26, 2014; doi:10.1152/ajpcell.00110.2013.—The process of wound healing must be tightly regulated to achieve successful restoration of injured tiss...

BACKGROUND Recent work suggests that injuries can heal faster if treated by lasers emitting 670-nm red light. LED lights emitting 670-nm light are now available. This suggests that inexpensive and easy-to-use 670-nm LED lights might help accelerate cutaneous wound healing. OBJECTIVE The objective was to evaluate the effect of 670-nm LED light on wound healing in SKH-1 hairless mice. METHODS...

Aims: To evaluate the expression of transforming growth factor β1 (TGF-β1) and fibroblast growth factor 2 (FGF-2) mRNA in stromal cells in response to injury in the presence of either TGF-β1 or FGF-2. It has been shown previously that heparan sulfate proteoglycans and FGF-2 are present transiently during wound repair in vivo and that an increase in TGF-β1 mRNA is detected rapidly after injury. ...

A complex series of events involving inflammation, cell migration and proliferation, ECM stabilisation and remodelling, neovascularisation and apoptosis are crucial to the tissue response to injury. Wound healing involves the dynamic interactions of multiple cells types with components of the extracellular matrix (ECM) and growth factors. Impaired wound healing as a consequence of aging, injury...