We prospectively compared the occurrence of Vibrio parahaemolyticus in patients and the environment in the Pacific Northwest. Inpatient and outpatient stool and wound specimens and water samples from 10 estuarine sites were cultured for V. parahaemolyticus over a period of 3 years. V. parahaemolyticus infections were detected in 13 patients (8 with gastroenteritis; 5 with wound infections), and...

INTRODUCTION The recent literature suggests that chronic wound biofilms often consist of multiple bacterial species. However, without appropriate in vivo, polybacterial biofilm models, our understanding of these complex infections remains limited. We evaluate and compare the effect of single- and mixed-species biofilm infections on host wound healing dynamics using a quantitative, in vivo, rabb...

Wound infection is a serious threat to patients, in particular those with septic wound infections, which result high mortality rates. Moreover, the treatment of infections antimicrobial-resistant and/or biofilm-forming pathogens can be challenging. Nisin, potent antimicrobial against Gram-positive bacterial pathogens, has been used food industry as preservative for decades. Silver approved by F...

Wound infections are a serious medical problem for patients with non-healing chronic wounds and burn injuries. The healing of these wounds is often compromised by colonisation of many different bacteria, predisposing patients to life-threatening infections. Infected wounds continue to represent a complex problem for both health professionals and patients. Bacterial infections are a critical com...

Understanding the pathology resulting from Staphylococcus aureus and Pseudomonas aeruginosa polymicrobial wound infections is of great importance due to their ubiquitous nature, increasing prevalence, growing resistance to antimicrobial agents, and ability to delay healing. Methicillin-resistant S. aureus USA300 is the leading cause of community-associated bacterial infections resulting in incr...

OBJECTIVES Deep sternal wound infections are significant and severe complications following cardiac surgery and substantially influence perioperative morbidity and mortality. We present the experience of our department using two different surgical treatments over a three-year period. METHODS Between January 2009 and December 2011, a total of 3274 cardiac procedures with complete median sterno...

The purpose of this study was to determine whether the application of platelet gel (PG) on cardiac surgery wound incisions would promote wound healing and reduce the subsequent incidence of postoperative infections, thereby decreasing the length of hospital stay and hospital costs. Previous work has shown increased incisional healing effect among coronary artery bypass graft patients who receiv...

HYPOTHESIS Application of skin sealant prior to incision reduces microbial contamination of the wound. DESIGN Prospective, randomized, multicenter clinical trial. SETTING Six teaching hospitals. PATIENTS A total of 177 adult patients undergoing elective open inguinal hernia repair were randomized to either standard skin preparation with 10% povidone-iodine or skin preparation followed by ...

Objective: Postoperative wound infections generally cause considerable extra morbidity, mortality and costs. As nowadays length of hospitalization shortens, post-discharge surveillance is important to get reliable information on the prevalence of postoperative wound infections. In this study, the prevalences of sternal wound (SWI) and donor site infections (DSI) during hospitalization as well a...

Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus are commonly associated with biofilm-associated wound infections that are recalcitrant to conventional antibiotics. As an initial means to identify agents that may have a greater propensity to improve clearance of wound-associated bacterial pathogens, we screened a Food and Drug Administration-approved drug library for m...