This study was designed to investigate dosimetric variations between proton plans with (PPW) and without (PPWO), a compensator for whole brain radiotherapy (WBRT). The retrospective study on PPW and PPWO in Eclipse and XiO systems and photon plans (XP) using controlled segments in Pinnacle system was performed on nine pediatric patients for craniospinal irradiations. DVHs and derived metrics, s...

Xeroderma pigmentosum (XP) is a skin cancer-prone autosomal recessive disease characterized by inability to repair UV-induced DNA damage. The major form of XP is defective in nucleotide excision repair (NER) and comprises seven complementation groups (A-G). The genes defective in all groups have been identified unambiguously with the exception of group E. The cells of some XP-E patients are def...

To extend our knowledge of the excision repair system in mammalian cells we have focussed on the isolation of genes and proteins involved in this process. For the purification and characterization of human repair proteins the microneedle injection assay technique is utilized. This system is based on the transient correction of the excision repair defect of xeroderma pigmentosum (XP) fibroblasts...

Colocation has come to be seen as a necessary precondition for obtaining the majority of the benefits of XP. Without colocation teams expect to struggle, to compromise and to trade off the benefits of XP vs the benefits of distributed development. We have found that you can stay true to the principles and not compromise the practices of XP in a distributed environment. Thus, business can realiz...

We conducted an experiment attempting to compare XP with a traditional approach to student software engineering projects. We tasked two groups of student teams with producing a simple room reservation system, one group following a traditional development process, the other using XP. We observed little actual difference between the products delivered by either process. However, in our opinion th...

s.t. T = Tinit with xp ∈ {0, 1}, p ∈ V. Here V is the regular image grid domain, and E denotes the 4or 8neighborhood in the image. The terms of the above energy function have the form D(xp) = E1 p(1− xp) + E0 pxp and Vpq(xp, xq) = wpq((1 − xp)xq + (1 − xq)xp) with wpq ≥ 0. In the image domain, we consider the case that all the 0’s (foreground) are 4-connected and all the 1’s (background) are 8-...

The recessive autosomal hereditary disease, xeroderma pigmentosum (XP), is characterized by a high incidence of tumors in sun-exposed skin. The defect in early steps of excision repair of XP cells leads to hypermutability towards UV-mimicking agents. DNA from eight XP tumors were screened for activated transforming genes using 3T3 transfection. In two skin tumors isolated from a XP child, an ac...

A high level of sequence polymorphism combined with linkage disequilibrium has created a limited number of highly diverged haplotypes across the human Xp/Yp telomere junction region. To gain insight into the unusual genetic characteristics of this region, we have examined the orthologous sequences in the common chimpanzee (Pan troglodytes ), the gorilla (Gorilla gorilla) and the orang-utan (Pon...

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by extreme sensitivity to actinic pigmentation changes in the skin and increased incidence of skin cancer. In some cases, patients are affected by neurological alterations. XP is caused by mutations in 8 distinct genes (XPA through XPG and XPV). The XP-V (variant) subtype of the disease results from mutations in a g...

purpose: to specify histopathologic features of corneal involvement in a case with xeroderma pigmentosum (xp). case report: a 19-year-old man with a clinical diagnosis of xp presented with bilateral corneal leukoma and decreased visual acuity predominatly in his right eye. penetrating keratoplasty was performed in the right eye due to severe corneal opacity, vascularization and lipid deposition...