1. Reiter A, Schrappe M, Luwdig WD, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 1994; 84:3122-33. 2. Wan JH, Trainor KJ, Brisco MJ, Morley AA. Monoclonality in B-cell lymphoma detected in paraffin wax embedded using the polymerase chain reaction. J Clin Pathol 1990; 43:888-90. 3. Brisco...

Murine L1210 leukemia cells resistant to the antineoplastic agent L-phenylalanine mustard have a 1.52.0-fold elevation in their cellular GSH and GSSG content as compared to drug-sensitive cells. Cellular uptake of ~-[U-'~C]cystine and its incorporation into GSH of the resistant tumor are correspondingly elevated. Synthesis of y-glutamylcysteine, GSH, and GSSG is elevated 1.5-2.0-fold in cell-f...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

Abstract Stereotyped B-cell receptors (BCR) are frequent in patients with chronic lymphocytic leukemia (CLL). In cell culture and mouse models of CLL, immunogenic epitopes these BCRs were shown to trigger specific T-cell responses control development. These results suggest vaccination autologous BCR-derived peptides as a novel therapy for CLL. See related article by Rovida et al., p. 729

Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase chronic myeloid leukemia. We report a case newly diagnosed patient with leukemia phase, infiltration right ovary on disease presentation. Case report. The presented abdominal pain, leukocytosis, anemia. A peripheral blood smear indicated leukemia, cytoreduc...

background: leukemia is a malignant proliferative disorder of the hematopoietic cells. the important role of angiogenesis in leukemia has been reported by several studies. matrix metalloproteinases (mmps) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. objective: the present study was conducted to evaluate the patterns of ...

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

Graft rejection after histocompatibility locus antigen (HLA)-identical stem cell transplantation results from the recognition of minor histocompatibility antigens on donor stem cells by immunocompetent T lymphocytes of recipient origin. T-lymphocyte clones that specifically recognize H-Y epitopes on male target cells have been generated during graft rejection after sex-mismatched transplantatio...

stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. stem cells are divided into two categories of embryonic and adult. in another categorization stem cells are divided to totipotent, multipotent and unipotent cells. so far usage of stem cells in treatment of various blood diseases has been studi...