Povzetek. Delo opisuje izdelavo teoretičnega in hibridnega mehkega modela šaržnega reaktorja. Reaktor se v farmacevtski industriji uporablja za izdelavo zdravil, kjer je potrebna hitra in natančna regulacija temperature vsebine reaktorja. Ker testiranje na realnem procesu pogosto ni mogoče, je izdelava teoretičnega modela šaržnega reaktorja potrebna za razvoj in testiranje prediktivnih regulaci...

The article reports the radiocarbon investigation of Anzapalivoro, the largest za baobab (Adansonia za) specimen of Madagascar and of another za, namely the Big cistern baobab. Several wood samples collected from the large inner cavity and from the outer part/exterior of the tree were investigated by AMS (accelerator mass spectrometry) radiocarbon dating. For samples collected from the cavity w...

It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against tumours not located in bone. Mice transgenic for the activated ErbB-2 oncogene were treated with a cumulative number of doses equivalent to that recommended in human beings. A significant increase in tumour-free and overall survival was observed in mice treated with ZA. At clinically compatible concentrati...

Adresa za dopisivanje Doc.dr.sc. Marko Jakovac Sveučilište u Zagrebu Stomatološki fakultet Zavod za fiksnu protetiku 10 000 Zagreb, Gundulićeva 5 Tel: 4802 123 [email protected] Sažetak Dentalna keramika danas je jedan od osnovnih gradivnih materijala u fiksnoj protetici. Naime, povećani estetski zahtjevi potaknuli su nastanak novih keramičkih materijala kako bi se izbjegla upotreba metalnog skel...

Povzetek. Izpostavitev bioloških celic električnemu polju visoke jakosti lahko povzroči elektroporacijo celičnih membran, to je nastanek prevodnih poti med celično notranjostjo in zunanjostjo. Elektroporacija se uporablja za transport različnih molekul preko celične membrane (reverzibilna elektroporacija) ali pa za ubijanje celic (ireverzibilna elektroporacija), kar je mogoče uporabljati tudi z...

Zoledronic acid (ZA) is a potent nitrogen-containing bisphosphonate with a long skeletal half-life that is administered annually by intravenous (IV) infusion. In the Horizon trial, ZA significantly reduced the risk of vertebral fracture by 70%, the risk of hip fracture by 40%, and the risk of nonvertebral fracture by 20% [1]. ZA also reduced the risk of clinical fracture by 35% and decreased mo...

BACKGROUND Bisphosphonates are potent inhibitors of bone resorption. These kinds of drugs, which are used for the treatment of osteolytic diseases, have been associated with the occurrence of oral osteonecrosis, especially in patients over 60 years old. Current studies have demonstrated that the cytotoxic effects of bisphosphonates on osteoblasts play an important role in oral osteonecrosis dev...

STRESZC ZE NIE Oste oin te gra cja jest pro ce sem po le ga ją cym na wy two rze niu trwa łe go po łą cze nia po mię dzy ko ścią bior cy i po wierzch nią wsz cze pu. Pro ces ten prze bie ga w funk cji cza su ja ki jest po trzeb ny do zro śnię cia się im plan tu z ko ścią. Isto tą pro ce su oste oin te gra cji jest osią gnię cie sta łej sta bil no ści wsz cze pu, co za pew nia pra wi dło wy prze...

drugs on oral mucosa cells. A previous study showed that 5 μM of zoledronic acid (ZA), a nitrogen-containing bisphosphonate, is the highest concentration of this drug found in the oral cavity of patients under treatment. Therefore, in order to simulate an osteonecrosis clinical condition, the aim of this study was to evaluate the highest concentration of ZA applied on human epithelial cells (Ha...

Toll like receptors (TLR) čine familiju transmembranskih signalnih proteina koji delujući kao senzori za produkte mikroorganizama započinju antimikrobni imunski odgovor. Do danas, kod sisara je poznato 12 TLR gena koji kodiraju isto toliko membranskih glikoproteina sa ekstracelularnim delom bogatim leucinom i intercitoplazmatskim delom sa homologijom (TIR). Toll-IL-1 receptor (TIR) domen sadrži...