OBJECTIVE To analyze adherence to the recommended iron, zinc and multivitamin supplementation guidelines for preemies, the factors associated with this adherence, and the influence of adherence on the occurrence of anemia and iron, zinc and vitamin A deficiencies. METHODS This prospective cohort study followed 58 preemies born in 2014 until they reached six months corrected age. The preemies ...

Zinc is an essential micronutrient which plays a macro role in the growth and productivity of the plants. Zinc (Zn) deficiency hinders metabolic and physiological activity in plants due to its inevitable role as an enzyme cofactor. Many Indian soil exhibit Zn deficiency with the content much below the critical level of 1.5ppm. The conditions that make unavailability of zinc to plants are high p...

Recent clinical and experimental studies suggest that zinc deficiency may play an important role in the pathogenesis of (1) acrodermatitis enteropathica, and in certain cases of (2) hypogonadal dwarfism, (3) congenital malformations, (4) hypogeusia and hyposmia, (5) nyctalopia and (6) impaired wound healing. Distrubances of zinc metabolism also occur in a broad spectrum of other clinical disord...

Zinc is an essential trace element that is required for the function of a large number of proteins. As these zinc-binding proteins are found within the cytosol and organelles, all eukaryotes require mechanisms to ensure that zinc is delivered to organelles, even under conditions of zinc deficiency. Although many zinc transporters belonging to the Cation Diffusion Facilitator (CDF) families have...

Zinc is an essential cofactor of all major eukaryotic RNA polymerases. How the activity of these enzymes is coordinated or regulated according to cellular zinc levels is largely unknown. Here we show that the stability of RNA polymerase I (RNAPI) is tightly coupled to zinc availability in vivo. In zinc deficiency, RNAPI is specifically degraded by proteolysis in the vacuole in a pathway depende...

People who supplement their diets with extra zinc usually have potentially harmful changes in lipoprotein metabolism. Because zinc can interfere with copper metabolism and copper deficiency has produced similar changes in lipid metabolism in animals and people, the hypothesis that lipid alterations from high zinc intakes are accompanied by changes in copper metabolism was tested. Progenies of s...

The three major eukaryotic RNA polymerases contain zinc. The presence of zinc cations bound to various polymerase subunits was determined by early work describing the purification of eukaryotic RNA polymerases, including RNA polymerase I (RNAP I), the enzyme that produces three of the four rRNAs. These pioneer studies also showed that zinc is required for the activity of various eukaryotic RNA ...

Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event. In addition to acute intoxication, long-term, high-dose zinc supplementation interferes with the uptake of copper. Hence, many of its toxic effects are in fact due to copper deficiency. While systemic home...