OBJECTIVE The objective of this study was to test if the proportion of new-onset diabetic subjects with the HLA-DR3/4-DQB1*0302 genotype is decreasing over time. RESEARCH DESIGN AND METHODS We analyzed HLA class II genotype frequencies over time in two large populations with type 1 diabetes diagnosed at ≤18 years of age. There were 4,075 subjects from the Type 1 Diabetes Genetics Consortium (...

Abstract. The Brewer–Dobson circulation (BDC) is a key feature of the stratosphere that models need to accurately represent in order simulate surface climate variability and change adequately. For first time, Climate Model Intercomparison Project includes its phase 6 (CMIP6) set diagnostics allow for careful evaluation BDC. Here, BDC evaluated against observations reanalyses using historical si...

Observational and modeling evidence suggest a recent acceleration of the stratospheric Brewer-Dobson circulation (BDC), driven by climate change ozone depletion. However, slowly varying natural variability can compromise our ability to detect such forced changes over relatively short observational record. Using observations chemistry-climate model simulations, we demonstrate link between multi-...

Solvent-mediated crystal-to-crystal transformations of [Au6Ag3Cu3(H2O)3(d-pen)6(tdme)2]3+ (d-[1(H2O)3]3+; pen2−=penicillaminate, tdme=1,1,1-tris(diphenylphosphinomethyl)ethane) to form unique supramolecular species are reported. Soaking crystals d-[1(H2O)3]3+ in aqueous Na2bdc (bdc2−=1,4-benzenedicarboxylate) yielded containing d-[1(bdc)(H2O)2]+ due the replacement a terminal aqua ligand by mon...

Zr-based MOFs have stimulated the interest of scientific community due to their exceptional variety in composition, structure and chemical environment as well consequent applications including photocatalysis. This work presents successful preparation nanosized highly-porous Zr-BDC under sustainable conditions: at room temperature, water sole solvent, with no modulators. approach solves some env...

Abstract In the present study, a facile solvothermal method was used for synthesis of silicotungstic acid (HSiW) immobilized on Ce-based metal organic framework (Ce-BDC) and embedded in Zr-based metal-organic (UiO-66(Zr)) composite catalyst, namely, Ce-BDC@HSiW@UiO-66 production biodiesel through green fatty esterification. The obtained hybrids were characterized by various characterization tec...

The sensitivities of the Brewer–Dobson circulation (BDC) to different distributions of tropical SST heating are investigated in an idealized aquaplanet model. It is found that an increase in tropical SSTs generally leads to an acceleration of tropical upwelling and an associated reduction in the age of air (AOA) in the polar stratosphere and that the AOA near the subtropical tropopause is corre...

BACKGROUND Intratumoral heterogeneity reflects subclonal diversity and accounts for a variety of clinically defined phenotypes including the development of drug resistance and recurrence. However, intratumoral heterogeneity of bile duct carcinoma (BDC) is rarely studied. METHODS Two highly heterogeneous cell lines named EH-CA1a and EH-CA1b were established from a primary tumor tissue of a pat...

The flexibility of eight aluminium hydroxo terephthalates [Al(OH)(BDC-X)]·n(guest) (BDC = 1,4-benzene-dicarboxylate; X = -H, -CH3, -Cl, -Br, -NH2, -NO2, -(OH)2, -CO2H) crystallising in the MIL-53-type structure was investigated upon thermal dehydration of as-made samples, superhydration and methanol adsorption/desorption using in situ powder X-ray diffraction (PXRD). Profile fitting was used to...

The gas-phase loading of [Zn4O(bdc)3] (MOF-5; bdc = 1,4-benzenedicarboxylate) with the volatile compound [Ru(cod)(cot)] (cod = 1,5-cyclooctadiene, cot = 1,3,5-cyclooctatriene) was followed by solid-state (13)C magic angle spinning (MAS) NMR spectroscopy. Subsequent hydrogenolysis of the adsorbed complex inside the porous structure of MOF-5 at 3 bar and 150 degrees C was performed, yielding ruth...