Background The extended spectrum ß-lactamases (ESBL) are enzymes that produce resistance to ß-lactam antibiotics, including penicillins, wide spectrum cephalosporins and aztreonam, by cleavage of ß-lactam ring (BUSH & JACOBY, 2010). Since ESBL-producing bacteria are frequently associated with nosocomial infections, treatment options are becoming increasingly limited (RAWAT & NAIR, 2010). In thi...

ß We develop an application to identify and characterize polygonal features in SAR images, based on a watershed algorithm, modified for a good robustness to radar noise. ß Our system performs a multi-scale analysis of the image. Oversegmentation is prevented by a selection of outstanding contours; regions with less prominent contours are merged ß This analysis is applied to Venus images from th...

Cholesterol has important functions in the organization of membrane structure and this may be mediated via the formation of cholesterol-rich, liquid-ordered membrane microdomains often referred to as lipid rafts. Methyl-beta-cyclodextrin (cyclodextrin) is commonly used in cell biology studies to extract cholesterol and therefore disrupt lipid rafts. However, in this study we reassessed this exp...

The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), a polysaccharide, sodium hyaluronate (NaHy), on the diffusion aqueous solutions cobalt chromium chlorides has been investigated. Cobalt are constituents metal alloys for biomedical use, including dental prostheses. Thus, release these ions in human body can lead to harmful biological effects. interaction with...

Fluorescence study on inclusion interaction of duloxetine in β-cyclodextrin shows significant increase in the fluorescence of duloxetine in the presence of β-cyclodextrin. The effects of pH and cyclodextrin concentration on the fluorescence spectra are reported. Fluorescence spectroscopy of the host-guest interaction between duloxetine and β-cyclodextrin shows formation of inclusion complex wit...

It is known that hydrocortisone can be converted to a potent angiogenesis inhibitor by coadministration with heparin or with a sulfated cyclodextrin. The activity of tetrahydrocortisol-S, a purely angiostatic corticosteroid, can be potentiated by beta-cyclodextrin tetradecasulfate as shown in this study. This drug "pair" and other pairs of corticosteroids and beta-cyclodextrin tetradecasulfate ...

The inclusion complexation behavior of azadirachtin with several cyclodextrins and their methylated derivatives has been investigated in both solution and the solid state by means of XRD, TG-DTA, DSC, NMR, and UV-vis spectroscopy. The results show that the water solubility of azadirachtin was obviously increased after resulting inclusion complex with cyclodextrins. Typically, beta-cyclodextrin ...

The aim of the presented work is the comparison of aqueous and 1-octanol solubilities of different acyclovir derivatives and their hydroxypropyl-β-cyclodextrin inclusion complexes. The solubility measurements were carried out at different temperatures over the range 25-45 °C using water, 1-octanol, water saturated with 1-octanol, 1-octanol saturated with water, buffered aqueous solutions (pH = ...