the presence of antibacterial activity in bovine β-lactoglobulin and in α-lactalbumin hydrolysates was investigated. the plasmin-digest of β-lactoglobulin (pdβ) and of α-lactalbumin (pdα) were fractionated, using reversed phase high performance liquid chromatography. the antibacterial activity of β-lactoglobulin, α-lactalbumin, nisin, plasmin, pdβ and pdα were in vitro tested against pathogenic...

background: β-thalassemia is an autosomal hemoglobinopathy with inconsistent universal distribution. among patients with thalassemia diverse non-siderotic complications distinctly influence the attribute of life, including zinc deficiency due to varied etiologies. the objective of the present study was to determine zinc levels in patients with β-thalassemia major and its correlation with matern...

hemoglobin f (hbf, α 2 γ 2 ) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the β-globin disorders including β-thalassemia and sickle cell disease (scd). during fetal life, hbf is the major hemoglobin but is largely substituted by adult hemoglobin (hba, α 2 β 2 ) following a globin expression switch after birth. increased γ-globin expressio...

background: in the previous study, we have shown that the presence of a allele at position -588 in aγ-globin gene was highly frequent and closely associated with fetal hemoglobin elevation among β-thalassemia intermedia patients. therefore, we decided to investigate whether this allele (a allele at -588) could result in an increase in aγ-globin gene expression to ameliorate the severity of the ...

background: efficient induction of fetal hemoglobin (hbf) is considered as an effective therapeutic approach in beta thalassemia. hbf inducer agents can induce the expression of γ-globin gene and produce high levels of hbf via different epigenetic and molecular mechanisms. thalidomide and sodium butyrate are known as hbf inducer drugs. material and methods : cd133 + stem cells were isolated fro...

Trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.An efficient epoxidation of β-CF3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and F5-substituted chiral qua...

Alkylpalladium complexes are important intermediates in several industrially relevant catalytic reactions, such as the Mizoroki–Heck reaction, alkyl C–H activation and ethylene polymerization. β-elimination—of either a hydride (β-Η) or heteroatom (β-Χ)—is most common decomposition pathway for these intermediates; this can lead to desired it hinder reaction progress, and/or vinyl halide co-polym...

Hemoglobin Abruzzo is an abnormal human hemoglobin with a substitution at a residue known to be involved in the binding of 2,3-diphosphoglyceric acid. It has increased oxygen affinity and reduced heme-heme interaction in the absence of organic or inorganic phosphate cofactors. In inorganic phosphate buffers the Bohr effect and heme-heme interaction are normal, but the oxygen affinity remains hi...

Cinnamomum longepaniculatum essential oil (CLEO) possesses antibacterial, anti-inflammatory, and antioxidant activities. However, CLEO shows volatilization poor solubility, which limits its application field. In this research, inclusion complexes of β-cyclodextrin (β-CD) with were produced, physicochemical properties characterized. Response surface methodology was used to obtain optimum prepara...