BACKGROUND The predominant hCG variant in urine, hCG β core fragment (hCGβcf), has been demonstrated to cause false-negative results in qualitative point-of-care (POC) hCG devices. This is a major concern for healthcare professionals using POC pregnancy tests. We developed a screening method to evaluate qualitative POC hCG devices for their susceptibility to inhibition by hCGβcf. Using this met...

Objective: To investigate clinicopathological characteristics of unusual gestational trophoblastic neoplasms (GTNs) that are difficult to be clearly classified. Methods: We retrospectively reviewed 455 GTNs treated and found three unusual cases. We investigated the morphology and immunostains of all three cases. Results: The three patients aged 25-42 years, the interval from the last gestation ...

OBJECTIVE To investigate the effect of associations in serum free β-hCG and PAPP-A between successive pregnancies on the performance of screening for trisomy 21 at 11-13 weeks' gestation. METHODS In 8,499 women with two consecutive pregnancies, including 49 women with fetal trisomy 21 in the second pregnancy, the correlation in serum free β-hCG multiples of the median (MoM) and PAPP-A MoM bet...

Objective To assess the efficacy and safety of ultrasound-guided intragestational injection of methotrexate (MTX) and systemic intramuscular MTX in the management of cesarean scar pregnancies. Methods This was a retrospective case-control study that included women diagnosed with cesarean scar pregnancy at CHA Bundang Medical Center unit between 2009 and 2015. The 26 cases were managed with lo...

OBJECTIVE To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS A review of medical records of patients with refractory gestational trophoblastic neoplasia who underwent pulmonary surgery and re...

This review examines human chorionic gonadotropin (hCG) or pregnancy tests from multiple perspectives. It first investigates the molecule hCG and shows that the term represents five independent molecules differing in carbohydrate and meric structure that share a common amino acid sequence. The review goes on to show that multiple degradation produces also the need to be tested for an hCG or pre...

The study was done with the aim to find out the effect of prophylactic chemotherapy on regression pattern of serum β-HCG and on the incidence of persistent trophoblastic disease in patients with high risk complete hydatidiform mole. Methods Out of 43 patients of complete hydatidiform mole diagnosed over a period of 1 year, 24 were categorised as high risk on the basis of Curry criteria. After s...

OBJECTIVE : To assess the diagnostic value of maternal CA 125 in patients with first trimester pregnancy and to evaluate the prognostic significance of CA 125 versus β-hCG in early pregnancies with intact fetal heartbeat, complicated by vaginal bleeding. .

Background: Majority of the reports suggest that frequency ectopic pregnancies have grown in last 30 years, especially patients conceived through artificial reproductive techniques (ART). To prevent severe morbidity and mortality its prompt diagnosis appropriate management is important. In a select patient population, most unruptured, live can be successfully managed without surgical interventi...