نتایج جستجو برای: ε4 allele
تعداد نتایج: 147786 فیلتر نتایج به سال:
OBJECTIVE The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and dementia. However, it remains unclear whether plasma levels of apoE confer additional risk. We tested this hypothesis. METHODS Using 75,708 participants from the general population, we tested whether low plasma levels of apoE at study enrollment were associated with increased risk of futur...
Background: Mild cognitive impairment (MCI), a heterogeneous status, has gained increased interest from clinicians and researchers, because it has been shown to represent a transitional stage between normal ageing and very early Alzheimer’s disease (AD). Neuroimaging data, genetic findings, biological markers and neuropsychological tests have been evaluated as predictors of conversion from MCI ...
Genome-wide association studies (GWAS) have identified one single-nucleotide polymorphism (SNP) rs9271192 within HLA-DRB1 as a risk factor for Alzheimer's disease (AD) in Caucasians. The effect of rs9271192 on AD needed to be verified in other ethnic cohorts. In order to evaluate the association between HLA-DRB1 rs9271192 polymorphism and late-onset AD (LOAD) in the Northern Han Chinese populat...
OBJECTIVE Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear. METHODS Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part o...
Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI) with tract-based spatial statistics to investigate apolipoprotein (APOE) ε4 modulation of white-matter damage in 37 patients with YOAD (22, 59% APOE ε4 positive) and 23 age-matched controls. ...
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