since the discovery of macc as a major metabolite of both endogenous and exogenously applied acc, it has become evident that the formation of macc from acc can act to regulate ethylene production in certain tissues. hence, it was suggested that macc could serve as an indicator of water-stress history in plant tissues. the accurate quantification of macc in plant tissues is essential for the und...

carnation etched ring virus (cerv) is a member of the caulimovirus genus of the caulimoviridae. the virus is the second most important virus of carnation around the world and the only dna virus among infecting viruses of carnation. the virus infected plants were collected from greenhouse in chenaran and two fragments of ~1500 bp and ~1000 bp respectively for coat protein and movement protein we...

abstract in this study a greenhouse experiment was conducted to evaluate the role of acc deaminase enzyme on alleviation of salinity stress of canola plant. canola plants were exposed to pseudomonas fluorescens strain p12 which contains a rhizobacter capable of producing pseudomonas fluorescens in comparison with plants exposed to mutant pm12 unable to produce the required enzyme. the mutant wa...

RATIONALE The energy sensor AMP-activated protein kinases (AMPK) is thought to play an important role in regulating myocardial fatty acid oxidation (FAO) via its phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC). However, studies supporting this have not directly assessed whether the maintenance of FAO rates and subsequent cardiac function requires AMPK-dependent inhibitor...

Chronic hyperglycemia is detrimental to pancreatic beta-cells, causing impaired insulin secretion and beta-cell turnover. The characteristic secretory defects are increased basal insulin secretion (BIS) and a selective loss of glucose-stimulated insulin secretion (GSIS). Several recent studies support the view that the acetyl-CoA carboxylase (ACC) plays a pivotal role for GSIS. We have shown th...

Background: For adrenocortical carcinoma (ACC), a rare endocrine malignancy with high rate of mortality and recurrence, it is difficult for clinicians to predict overall survival select the most effective treatment. Targeting ferroptosis, form cell death, has been reported be promising therapeutic strategy ACC; however, core ferroptosis regulator its prognostic value in ACC remain unknown.

We have cloned and sequenced the cDNA coding for human HepG2 acetyl-CoA carboxylase (ACC; EC 6.4.1.2). The sequence has an open reading frame of 7038 bp that encode 2346 amino acids (M(r), 264,737). The C-terminal 2.6-kb sequence is very different from that recently reported for human ACC (Ha, J., Daniel, S., Kong, I.-S., Park, C.-K., Tae, H.-J. & Kim, K.-H. [1994] Eur. J. Biochem. 219, 297-306...

Inhibition of growth of the apicomplexan parasite Toxoplasma gondii by aryloxyphenoxypropionate herbicides has been correlated with the inhibition of its acetyl-CoA carboxylase (ACC) by these compounds. Here, full-length and C-terminal fragments of T. gondii apicoplast ACC as well as C-terminal fragments of the cytosolic ACC were expressed in Escherichia coli. The recombinant proteins that were...