The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc expression. Inhibition of ornithine decarboxylase, an enzyme of the polyamine biosynthetic pathway and a Myc target, has been shown to be...

OBJECTIVE Millions of patients experience the disabling hand manifestations of rheumatoid arthritis (RA), yet few hand-specific instruments are validated in this population. Our objective was to assess the reliability, validity, and responsiveness of the Michigan Hand Questionnaire (MHQ) in patients with RA. METHODS At enrollment and at 6 months, 128 RA patients with severe subluxation of the...

The recent discovery of the "Stress Repair Mechanism" (SRM) enables the Unified Theory of Medicine postulated by Hans Selye. It confers cohesive theories of anesthesia, analgesia, and allostasis that enable the alteration of anesthetic technique to optimize surgical outcome. The SRM continuously maintains and repairs the vertebrate body in accord with stressful forces and stimuli. Three synergi...

Protein turnover represents an important mechanism in the functioning of cells, with deregulated synthesis and degradation of proteins implicated in many diseased states. Therefore, proteomics strategies to measure turnover rates with high confidence are of vital importance to understanding many biological processes. In this study, the more widely used approach of non-targeted precursor ion sig...

This paper presents the design, and simulation of a soft switched boost converter for a switched reluctance motor with a closed loop controller. A soft switching scheme is proposed in the converter with minimum components, which reduces the switching loss and stress across the switch so that the harmonic generation is reduced in the output. The switch used in this converter switched ON at zero ...

This paper presents a sliding mode observer for sensorless operation of SRM (switched reluctance motor) drive. Design of such an observer depends mainly on the nonlinear model of SRM. In this technique, neither extra hardware nor huge memory space arenot required but it only requires active phase measurements. Furthermore, PI (proportional integral) are suggested to operate individually along w...

This paper proposes a flat bottom driving method for switched reluctance motor (SRM) by using full-bridge power converter. Based on ring structure, an SRM is able to be driven inverter. With the proposed topology, adding harmonics in sinusoidal current waveform from space vector PWM (SVPWM) method, can generated SRM. According theoretical analysis and calculation, reduces copper loss, compared ...

The paper presents a state of the art review on the subject of torque ripple, vibrations, and acoustic noise in Switched Reluctance Motors (SRM). The approach of the multi-phase operation of SRM is also reviewed. Moreover, further directions of research on these subjects are introduced.

Protection Objectives Sensitive information protection IPR protection Privacy protection Protection Architectures Server-side reference monitor Client-side reference monitor SRM & CRM Server-side Reference Monitor (SRM) Client-side Reference Monitor (CRM) Traditional Access Control Trust Management Usage Control Sensitive Information Protection Intellectual Property Rights Protection Privacy Pr...

The collection, processing and certification of a new sediment Standard Reference Material (SRM), SRM 2704, is described. Collected from the bottom of the Buffalo River in New York State during the fall of 1986, SRM 2704 is certified for 25 elements with information provided on another 22 elements. Improvements in analytical methods as well as the application of well-defined quality-control pro...