BACKGROUND AND GOAL Patients infected with hepatitis C virus (HCV) with elevated low-density lipoprotein (LDL) levels achieve higher sustained virologic response (SVR) rates after peginterferon (PegIFN)/ribavirin treatment versus patients with lower LDL. Our aim was to determine whether SVR rates in patients with low/elevated LDL can be improved by dose intensification. STUDY In PROGRESS, gen...

BACKGROUND Novel direct-acting antiviral DAA combination therapies tremendously improved sustained virologic response (SVR) rates in patients with chronic HCV infection. SVR is typically accompanied by normalization of liver enzymes, however, hepatic inflammation, i.e. persistently elevated aminotransferase levels may persist despite HCV eradication. Aim: To investigate prevalence and risk fact...

AIM To investigate the influence of interferon-free antivirus therapy on lipid profiles in chronic hepatitis C virus genotype 1b (HCV1b) infection. METHODS Interferon-free antiviral agents were used to treat 276 patients with chronic HCV1b infection, and changes in serum lipids of those who achieved sustained virologic response (SVR) were examined. The treatment regimen included 24 wk of dacl...

BACKGROUND Despite significant advances in the treatment of chronic hepatitis C in the past decades, factors which can affect response rates to combination therapy; peginterferon and ribavirin, are still under study and reaching sustained virological response (SVR) is affected by several different factors. OBJECTIVES To investigate predictor factors contributing to SVR in Iranian patients. ...

AIM OF THE STUDY To assess predictors of sustained virological response (SVR) in patients with chronic hepatitis C virus (HCV) genotype 3 treated with standard therapy. MATERIAL AND METHODS We retrospectively investigated data of 116 consecutive treatment-naïve patients chronically infected with HCV genotype 3, treated with pegylated interferon alpha (PegIFNα) and ribavirin (RBV) for 24 weeks...

BACKGROUND The effects and efficacy of surgical ventricular restoration (SVR) in ischemic cardiomiopathy caused by chronic anterior myocardial infarction (MI) are well established. Normally, SVR is delayed at least 3 months after MI to allow the healing of infarcted tissue. Some patients have instability <30 days after anterior MI, with increased risk for morbidity and mortality.Objectives- Thi...

UNLABELLED Pegylated interferon alfa-2a (PEG-IFN) may induce sustained virological response (SVR) in 20% of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. In addition, loss of hepatitis B surface antigen (HBsAg) is achieved with a 10% yearly rate after treatment cessation in sustained responders. The aim of this study was to assess on-treatment serum HBsAg kinetics t...

In order to accurately predict China’s future total energy consumption, this article constructs a random forest (RF)–sparrow search algorithm (SSA)–support vector regression machine (SVR)–kernel density estimation (KDE) model forecast consumption in 2022–2030. It is explored whether China can reach the relevant target 2030. This begins by using screen for influences be used as input set model. ...

Recent work shows that Support vector machines (SVMs) can be solved efficiently in the primal. This paper follows this line of research and shows how to build sparse support vector regression (SVR) in the primal, thus providing for us scalable, sparse support vector regression algorithm, named SSVR-SRS. Empirical comparisons show that the number of basis functions required by the proposed algor...

This paper discusses the application of support vector machine in the area of identification of nonlinear dynamical systems. The aim of this paper is to identify suitable model structure for nonlinear dynamic system. In this paper, Adaptive Neuro Fuzzy Inference Systems (ANFIS) and Support Vector Regression (SVR) models are applied for identification of highly nonlinear dynamic process. The res...