Pyruvate carboxylase [EC 6.4.1.11 is a biotindependent enzyme that catalyses the carboxylation of pyruvate to form oxaloacetate (for a review see [ 11). The overall reaction proceeds in two stages, in the first stage the biotin prosthetic group is carboxylated by H Q with concomitant cleavage of MgATP. The carboxybiotin then moves to another part of the active site where the carboxyl group is t...

Journal of Polymer ScienceVolume 61, Issue 10 p. i-i COVER IMAGEFree Access Cover Image, Volume First published: 15 May 2023 https://doi.org/10.1002/pol.20230229AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read accept the ...

Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D. Li Puma, Tingyu Liu, Jane Hayes, Mychica R. Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D. Gale, Chi-hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L. Straudinger, Frank-Gerrit Klärner, Thomas Schrader, Sally A. Frautschy, Clau...

Aida M. Herrera, Richard J. Staples, Sergey V. Kryatov, Alexander Y. Nazarenko* and Elena V. Rybak-Akimova* a Department of Chemistry, Tufts University, Medford, Massachusetts, 02155, USA b Department of Chemistry, Chemical Biology, Harvard University, Cambridge, Massachusetts, 02138, USA c Department of Chemistry, State University of New York, College at Buffalo, Buffalo, New York, 14222-1095,...

To the Editor: In patients with ST-segment elevation myocardial infarction (STEMI), direct intracoronary as compared with standard intravenous bolus administration of the glycoprotein IIb/IIIa receptor antagonist abciximab acutely causes higher local drug concentrations, greater glycoprotein IIb/IIIa receptor occupancy, and enhanced inhibition of platelet aggregation at the site of thrombus and...