background: rna interference-based gene silencing has recently been applied as an efficient tool for functional gene analysis. rorc2 is the key transcription factor orchestrating th17 cells differentiation, the cells that are known as the pathogenic elements in various autoimmune diseases. the aim of this study was to design efficient sirnas specific for rorc2 and to evaluate different criteria...

نم أشنت .ةردان ةديمح ماروأ يه )ةيفيللا( ةيطابرلا مارولأا عباط تاذ يهو .مسلجا ءاحنأ عيمج يف ةيلضعلا لكايهلا لدعم عافترا ىلإ ىدأ امم ، ةرواجلما هيللمحا ةجسنلأل يحاشترا ةردنل ًارظن و .يحارلجا لاصئتسلاا دعب مرولا عوجر ةبسنو نع غلابلإاب انمق اننإف ، ةبقرلاو سأرلا ةقطنم يف مارولأا هذه يف اهجلاعو قنعلا ىلعأ يف يطابرلا مرولاب اهصيخشت تم ةلاح جلاعل هرفوتلما تارايلخاو قرطلا لوح يعولا ةدايزل ،انافشتسم .ةبق...

In this study, we investigated the ability of curcumin alone or in combination with GLUT1 siRNA to radiosensitize laryngeal carcinoma (LC) through induction autophagy. Protein levels tumour tissues and LC cells were measured by immunohistochemistry Western blotting. vitro, cell proliferation, colony formation assays, death autophagy detected. A nude mouse xenograft model was established injecti...

This paper constructs fully parallel NN hardware architecture, FPGA has been used to reduce neuron hardware by design the activation function inside the neuron without using lookup table as in most researches, to perform an efficient NN. It consist of two main parts; the first part covers network training using MATLAB program, the second part represents the hardware implementation of the traine...

ةـصلاخلا : ةلاحلا رايعم ثحبلا اذه يف ضرعن – ةلاحلا حشرمُــل لماشلا يبراقتلا تابثلل غارفلا – يمقرلا غارفلا عبشملا يباسحلا ضئافلا مادختساب كلذو ةددحم ةميق اذ . دقو ماظنلل ةديدج ةيصاخ ءاصقتساب رايعملا قُـتشأ ةساردلا ديق . اس رايعم عم رايعملا اذه ةنراقمب انمق امآ جنيسو راآ نم لٍآ لَـبـقِ نم هضرع مت قب . دقو جنيسو راآ رايعم نم لقأ طباوض يذ يلاحلا رايعملا نأ ةنراقملا تنابأ . و نع حرتقملا رايعملا ةعاجن ان...

In this paper, we describe denaturing and non-denaturing ion-pair reversed-phase liquid chromatography (RPLC) methods for analyzing small interfering ribonucleic acid (siRNA). Drug formulations consisting of one or two siRNA duplexes were analyzed in conditions at a low column temperature to separate intact from single-stranded oligonucleotide contaminants quantify them. method, used an elevate...