Imatinib mesylate (IM) is a small molecule inhibitor of protein tyrosine kinases. In addition to its direct effect on malignant cells, it has been suggested IM may activate of natural killer (NK) cells, hence exerting immunomodulatory functions. In preclinical settings, improved antitumor responses have been observed when IM and interleukin-2 (IL-2), a cytokine that enhances NK cells functions,...

Autophagy is a bulk degradation system mediated by biogenesis of autophagosomes under starvation conditions. In Saccharomyces cerevisiae, a membrane sac called the isolation membrane (IM) is generated from the pre-autophagosomal structure (PAS); ultimately, the IM expands to become a mature autophagosome. Eighteen autophagy-related (Atg) proteins are engaged in autophagosome formation at the PA...

BACKGROUND The Infobutton Manager (IM) is an application that provides clinical users with context-specific links to health information resources. Usage of the first version (IM-1) suggested that the user interface was suboptimal. METHODS We conducted a laboratory-based observational study of IM-1, use, applied standard user interface design techniques to address observed problems, developed ...

Aktuelle Forschungsaktivitäten im Bereich der Datenstromverarbeitungssysteme untermauern die zunehmende Bedeutung von Datenströmen, etwa im Kontext von Sensornetzwerken und im Bereich e-Science. Mit der zunehmenden weltweiten Vernetzung experimentell arbeitender Wissenschaftler ist die Entwicklung von Datenstrom-ManagementSystemen (DSMS) zur Informationsgewinnung aus im Netz veröffentlichten Me...

Research on computer-mediated communication (CMC) has thus far largely overlooked instant messaging (IM), an extremely popular, and increasingly important, form of CMC. This study examines the most prevalent motivations for using IM within what is currently among the largest demographic groups utilizing this tool, college students. Data from 271 students are used to assess current motivations f...

We previously developed IM-54 as a novel type of inhibitor of hydrogen-peroxide-induced necrotic cell death. Here, we examined its cell death inhibition profile. IM-54 was found to selectively inhibit oxidative stress-induced necrosis, but it did not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-17, an IM derivative having improved water-solubility and ...

Rapid-acting intramuscular (IM) formulations of atypical antipsychotics offer a significant advance over IM haloperidol in the short-term management of acute schizophrenic episodes. Several short-term open-label randomised studies, typically enrolling two- to three-hundred patients, have compared an atypical antipsychotic with haloperidol. These studies show that IM ziprasidone, IM olanzapine a...

BACKGROUND There have not been any reports in Japan clarifying the efficacy and safety of intramuscular (IM) olanzapine and IM levomepromazine in agitated elderly patients with schizophrenia. This study was a comparative investigation of the clinical efficacy and safety of IM olanzapine and IM levomepromazine in agitated elderly patients with schizophrenia at 2 hours post-dose. METHODS The su...

OBJECTIVES To determine whether any difference exists in responses to indirect moxibustion (IM) relative to thermal stimulation duration. METHODS In experiment 1, 9 subjects attended two experimental sessions consisting of single stimulation with IM or triple stimulation with IM, using a crossover design. A K-type thermocouple temperature probe was fixed on the skin surface at the GV14 acupun...

Atrophic gastritis (AG) and intestinal metaplasia (IM) are the main precursor lesions of gastric cancer as the incidence of gastric cancer increases in the gastric mucosa involved with AG and IM. The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation. Usually AG is antecedent of IM but the etiologies of AG and IM are not always the same. T...