BACKGROUND Inflammatory bowel diseases (IBD), including mainly ulcerative colitis (UC) and Crohn's disease (CD), are inflammatory disorders of the gastrointestinal tract caused by an interplay of genetic and environmental factors. Murine colitis model induced by Dextran Sulfate Sodium (DSS) is an animal model of IBD that is commonly used to address the pathogenesis of IBD as well as to test eff...

BACKGROUND Acrylamide (ACR) exposure is associated with neurotoxicity, carcinogenicity, and reproductive toxicity. The use of soy sauce as a condiment is common and it has been found that it possesses high antioxidant activity. The objective of the current study is to evaluate the protective role of dark soy sauce (DSS) against ACR-induced neurotoxicity in rats. MATERIALS AND METHODS Thirty-f...

Objective: The current study was conceived and performed to assess the pathophysiological, histological, and molecular manipulations of dextran sodium sulphate (DSS; MW: 5,000 Da) intervention in the rat and determined the changes in the antioxidant capacity of host and representative antioxidant enzymes. Methods: Wistar rats were fed with two different concentrations (3 and 5%) of DSS for seve...

BACKGROUND Ligamentum flavum (LF) hypertrophy is a common cause of lumbar spinal stenosis and is thought to be degeneration-driven. Developmental spinal stenosis (DSS) is characterized by pre-existing narrowed spinal canals and is likely a developmental problem that occurs in childhood. In these cases, the LF may demonstrate different characteristics as compared to degeneration-driven stenosis....

BACKGROUND Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. METHODOLOGY/PRINCIPAL FINDINGS Based on a prospective study, we analyzed the genome-wide expression profiles of whole blood ...

Emu Oil (EO) previously demonstrated therapeutic potential in a mouse model of colitis-associated CRC (CA-CRC). Saireito, traditional Japanese medicine, has not been investigated CA-CRC. To determine whether EO and Saireito could be an azoxymethane (AOM)/dextran sulphate sodium (DSS) Female C57BL/6 mice were assigned to groups (n = 10/group); 1) saline control, 2) saline+Saireito, 3) saline+EO,...

BACKGROUND Increased mucosal permeability is an important factor in the genesis of mucosal inflammation in inflammatory bowel disease. This study examined the time course of increased permeability and the effect of butyrate on permeability in experimental colitis in rats. METHODS Colitis was induced in albino rats by administration of 4% dextran sulphate sodium (DSS) orally for up to 7 days. ...

a r t i c l e i n f o This study investigates decision support systems (DSS) by assessing the factors that enhance their perceived effectiveness and their impact on performance. This was achieved by using a simulation exercise with 652 senior graduate students who developed DSS and reported on the systems created. Our analysis shows that DSS users who perceive the system as effective correlate ...