The species in the genus Oryza, encompassing nine genome types and 23 species, are a rich genetic resource and may have applications in deeper genomic analyses aiming to understand the evolution of plant genomes. With the advancement of next-generation sequencing (NGS) technology, a flood of Oryza species reference genomes and genomic variation information has become available in recent years. ...

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T he Clreat Paracelsus (Philipus Aureolus Theophrastus Bonihastus von Hohenheini-Paracelsus, 1493-1541) is remembered by toxicologists for his famous quote: "All substances are poisons; there is none which is not a poison. Tlie right dose differtntiates a poison from a remedy-"' Intieed, tiic l)iisic principle from the quotation still applies today. The right dose of morphine that will produce ...

DURING measurements of pressure in the small veins of a dog's hindleg, it was observed that fluctuations in pressure, associated with respiration, varied considerably from animal to animal. In some instances, venous pressure fell during the inspiratory phase; in other instances, venous pressure rose. In addition, spontaneous pressure changes, seemingly independent of respiratory movements, were...

This report details a Phase I dose-ranging experiment of the use of emetine in patients with a variety of malignant diseases. The data show that emetine can be given intravenously a t 4-day intervals with minimal toxicity. Severe muscle weakness, the most important dose-limiting toxic effect, began a t approximately a 15 mg/kg cumulative dose level and resulted in discontinuance of therapy i n ...

In this article we consider the problem of pricing lookback options in certain exponential Lévy market models. While in the classic Black-Scholes models the price of such options can be calculated in closed form, for more general asset price model one typically has to rely on (rather time-intense) MonteCarlo or P(I)DE methods. However, for Lévy processes with double exponentially distributed ju...

We solve the problem of pricing and hedging Asian-style options on energy with a quadratic risk criterion when trading in the underlying future is restricted. Liquid trading in the future is only possible up to the start of a so-called delivery period. After the start of the delivery period, the hedge positions can not be adjusted anymore until maturity. This reflects the trading situation at t...

A procedure is described for the direct determination of methyl derivatives of basic amino acids in total acid hydrolyzates of proteins by the use of a Beckman amino acid analyzer operated in the high sensitivity mode with automatic integration. The conditions described permit the separation of ornithine, lysine, 5-hydroxylysine, N’-monomethyllysine, N”-dimethyllysine, histidine, N’-methylhisti...

Kinetin and kinetin ribofuranoside have been tested on tissue cultures of adult human skin, breast carcinomas, and cystic disease of the breast. Outgrowths of epi thelium from skin cultures were retarded by kinetin and completely inhibited by kinetin ribofuranoside when treated with 1.0 mg. per cent. A concentration of 0.1 mg. per cent of kinetin had no effect on the extent or population of cel...

The traditional multivariate Lévy process constructed by subordinating a Brownian motion through a univariate subordinator presents a number of drawbacks, including the lack of independence and a limited range of dependence. In order to face these, we investigate multivariate subordination, with a common and an idiosyncratic component. We introduce generalizations of some well known univariate ...