The orientation of the TATA box is thought to direct downstream transcription of eukaryotic genes by RNA polymerase II. However, the putative TATA box in the promoter of the bone sialoprotein (BSP) gene, which codes for a tissue-specific and developmentally regulated bone matrix protein, is inverted (5'-TTTATA-3') relative to the consensus TATA box sequence (5'-TATAAA-3') and is overlapped by a...

The Bulk-Synchronous Parallel (BSP) model of computation has been proposed by L.G. Valiant as a unifying and bridging model for the design, analysis and implementation of parallel algorithms that are both scalable and portable, among diverse parallel machines. In this work we present direct BSP algorithms for dense matrix computations such as matrix multiplication, LU decomposition, determinant...

We show that the Bulk Synchronous Parallel (BSP) model, originally designed for distributed-memory systems, is also applicable for shared-memory multicore systems and, furthermore, that BSP libraries are useful in scientific computing on these systems. A proofof-concept MulticoreBSP library has been implemented in Java, and is used to show that BSP algorithms can attain proper speedups on multi...

A major challenge for parallel computing is the development of a standardized combination of portable and efficient parallel programming. An interesting approach towards this major goal is the research with offspring in Leslie Valiant’s Bulk Synchronous Parallel Model (BSP). The BSP model is a theoretical framework outlining how parallel computations can be organized in a way that bridges the g...

Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and the significance of the receiver operator characteristic (ROC) curve in...

The bulk-synchronous parallel (BSP) model of computing has been proposed to enable the development of portable software which achieves scalable performance across diverse parallel architectures. A number of applications of computing science have been demonstrated to be e ciently supported by the BSP model in practice. In this thesis we study the e cient realisation of parallel discrete-event si...

Fibroblast growth factor 2 (FGF2), a member of the FGF family, positively regulates bone formation and osteoblast differentiation. Bone sialoprotein (BSP) is highly expressed during early bone formation and may play a role in primary mineralization of bone. In the present study, FGF2 (10 ng/mL) was found to increase the levels of Runx2 and BSP mRNA at 3 and 12 h in human osteoblast-like Saos2 c...

Bulk Synchronous Parallel ML or BSML is a functional dataparallel language for programming bulk synchronous parallel (BSP) algorithms. The execution time can be estimated and dead-locks and indeterminism are avoided. For large scale applications, more than one parallel machine is needed. We consider here the design and cost-model of a BSML-like language devoted to the programming of such applic...

The Bulk Synchronous Parallel (BSP) programming model is studied in the context of sparse matrix computations. As a case study, a BSP algorithm is developed for sparse Cholesky factorisation.

BACKGROUND Intravoxel incoherent motion (IVIM) imaging of diffusion and perfusion in the heart suffers from high parameter estimation error. The purpose of this work is to improve cardiac IVIM parameter mapping using Bayesian inference. METHODS A second-order motion-compensated diffusion weighted spin-echo sequence with navigator-based slice tracking was implemented to collect cardiac IVIM da...