Using a continuous flow apparatus, the solubility of tridodecylamine (TDA) in supercritical CO2 (scCO2), have been measured at temperatures of 308, 318, and 328 K in the pressure range of (8-40) MPa and a flow rate of 150 ± 10 mL min. At 308 and 318 K the solubility increases with pressure up to 15 MPa where it reaches a plateau. At 328 K the solubility increases with pressure up to 35 MPa and ...

Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-microbial machinery of the innate immune system may boost host defence responses. H...

Building upon Beaudry and Koop’s (1993) analysis, we consider a “current depth of the recession” (CDR) variable in modeling the time series behavior of the postwar quarterly U.S. unemployment rate. The CDR approach is consistent with the state-dependent behavior in the unemployment rate documented in the business cycle asymmetry literature. We show that while the CDR effect is significant in-sa...

Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modulate the blood retina barrier (BRB). Here we gain insight on the basis of the pathology of a FEVR implicated F328S Fz4 mutant by study. The receptor exhibits a...

Running title: A CRISPR/Cas9 toolbox for gene editing and transcriptional regulation 1 2 3 Co-corresponding authors: 4 Yiping Qi, Department of Biology, East Carolina University, Greenville, North Carolina 27858; 5 Phone: 252-328-9764; Fax: 252-328-4178, Email: [email protected] 6 7 Yong Zhang, Department of Biotechnology, School of Life Sciences and Technology, University 8 of Electronic Science and...

Running title: A CRISPR/Cas9 toolbox for gene editing and transcriptional regulation 1 2 3 Co-corresponding authors: 4 Yiping Qi, Department of Biology, East Carolina University, Greenville, North Carolina 27858; 5 Phone: 252-328-9764; Fax: 252-328-4178, Email: [email protected] 6 7 Yong Zhang, Department of Biotechnology, School of Life Sciences and Technology, University 8 of Electronic Science and...

MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene regulators that bind mRNA in a sequence-specific manner. Here, we report that loss of miR-328 occurs in blast crisis chronic myelogenous leukemia (CML-BC) in a BCR/ABL dose- and kinase-dependent manner through the MAPK-hnRNP E2 pathway. Restoration of miR-328 expression rescues differentiation and impairs survi...

Neuropathy 3 Krish Chandrasekaran, Muragundla Anjaneyulu , Tatsuya 4 Inoue Joungil Choi, Avinash Rao Sagi, Chen Chen, Tamomi 5 Ide and James W. Russell. 6 1 Department of Neurology, University of Maryland, Baltimore, Maryland, USA, 2 VA 7 Maryland Health Care System; Principal Investigator, Preclinical Division, Syngene 8 International Ltd., Bangalore, India; Associate Senior Researcher, group ...

The ultraviolet absorption spectrum of vitamin A with itsmaximum near 328 m,. was described nearly 20 years ago (Morton & Heilbron, 1928a, b). The intensity of absorption shown at that wave length by a fish-liver oil or concentrate was conveniently expressed in terms of E "lo 328 m,u. (Gillam & Morton, 1929), and this magnitude was early seen to afford a guide to potency. If a number of fish-li...

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