Genetic factors have historically been thought of as important in the development of obsessive-compulsive disorder (OCD). For the estimation of the relative importance of genetic and environmental factors, twin studies are an obvious approach. Twin studies of OCD have a long history, starting in 1929. In this review, over 70 years of twin research of OCD is presented, using four different appro...

BACKGROUND It is often suggested that, in general, co-morbid personality disorders are likely to interfere with CBT based treatment of Axis I disorders, given that personality disorders are regarded as dispositional and are therefore considered less amenable to change than axis I psychiatric disorders. AIMS The present study aimed to investigate the impact of co-occurring obsessive-compulsive...

Obsessive-compulsive disorder (OCD) is a distressing and often debilitating disorder characterized by obsessions, compulsions, or both that are time-consuming and cause impairment in social, occupational, or other areas of functioning. There are many published studies reporting higher risk of suicidality in OCD patients, as well as studies describing increased risk of suicidality in OCD patient...

BACKGROUND Thalamic dysfunction has been implicated in obsessive-compulsive disorder (OCD). While OCD frequently has its onset during childhood, to our knowledge, no prior study has measured neuroanatomical changes in the thalamus of patients with OCD near the onset of illness, and before and after treatment. METHODS Volumetric magnetic resonance imaging studies were conducted in 21 psychotro...

BACKGROUND Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing a...

OBJECTIVE Evidence suggests that early-onset obsessive-compulsive disorder (OCD) is an etiologically distinct subtype of OCD. The objective of the present work was to search for neurocognitive endophenotypes of early-onset OCD based on assessments of attention, memory, and executive function in patients with the disorder and their unaffected siblings. METHODS We compared the performance of 40...

Although Obsessive-Compulsive Disorder (OCD) and Depression are classified as separate disorders, the high incidence of co-morbidity and the strong correlations between measures of each has led to debate about the nature of their relationship. Some authors have proposed that OCD is in fact a mood disorder while others have suggested that the two disorders are grounded in negative affectivity. A...

objective: the present study aimed to explore the relationship between worry and obsessive compulsive symptoms. we examined the correlations between the padua inventory (pi) and the penn state worry questionnaire (pswq) to further explore the distinctiveness of the pi. method: seventy-five subjects (n=40 male, n= 35 female) were selected from hafez hospital (iran) for this study: the subjects i...

objective: the present study aimed to investigate the metacognitive model of obsessive-compulsive disorder (ocd), through a comparative study of thought fusion beliefs and thought control strategies between patients with ocd, depression, and normal people. methods: this is a causal-comparative study. about 20 patients were selected with ocd, and 20 patients with major depression disorder (mdd),...