Human and rodent solid tumors often exhibit elevated interstitial fluid pressure (IFP). This condition is recognized as a prognostic indicator for reduced responses to therapy and decreased disease-free survival rate. In the present study, we tested whether induction of a thermoregulatory-mediated increase in tissue blood flow, induced by exposure of mice to mild environmental heat stress, coul...

Human and rodent solid tumors often exhibit elevated interstitial fluid pressure (IFP). This condition is recognized as a prognostic indicator for reduced responses to therapy and decreased disease-free survival rate. In the present study, we tested whether induction of a thermoregulatory-mediated increase in tissue blood flow, induced by exposure of mice to mild environmental heat stress, coul...

We have previously shown that osteosarcomas (OS) have states of increased interstitial fluid pressure (IFP), which correlate with increased proliferation and chemosensitivity. In this study, we hypothesized that constitutively raised IFP in OS regulates angiogenesis. Sixteen patients with the clinical diagnosis of OS underwent blood flow and IFP readings by the wick-in-needle method at the time...

High interstitial fluid pressure (IFP) in solid tumors is associated with reduced blood flow as well as inadequate delivery of therapeutic agents such as monoclonal antibodies. In the present study, IFP was measured as a function of radial position within two rat tissue-isolated tumors (mammary adenocarcinoma R3230AC, 0.4-1.9 g, n = 9, and Walker 256 carcinoma, 0.5-5.0 g, n = 6) and a s.c. tumo...

The effect of dexamethasone on interstitial hypertension was evaluated in a human colonic adenocarcinoma. Two weeks after transplantation of the tumor line LS174T into SCID mice, recipients with tumors > 8.5 mm in diameter received one daily injection i.p. on days 1-4, at five different doses in the range of 0.3-30 mg/kg. Controls received saline. The interstitial fluid pressure (IFP) was deter...

Address correspondence to: Dr. Chintan Modi, Saint Michael’s Medical Center, 111 Central Avenue, Newark, NJ 07102; Tel: 973-877-5351; Fax: 973-877-2984; E-mail: [email protected] The inflammatory fibroid polyp (IFP) is an uncommon benign tumor of the gastrointestinal tract. The tumor was first described in 1949 by Vanek as a gastric submucosal granuloma with eosinophilia.1,2 It has also been...

Let Q be a nite set of generalized quantiiers. By L k (Q) we denote the k-variable fragment of FO(Q), rst order logic extended with Q. We show that for each k, there is a PFP(Q)-deenable linear pre-order whose equivalence classes in any nite structure A are the L k (Q)-types in A. For some special classes of generalized quantiiers Q, we show that such an ordering of L k (Q)-types is already dee...

A 64-year-old man was referred to our hospital due to anemia and occult gastrointestinal bleeding. Small bowel barium enteroclysis revealed a well-rounded, semipedunculated protrusion, covered with a smooth surface, appearing to be a soft filling defect at the distal ileum measuring 20 mm in diameter (Picture 1). Next, balloon enteroscopy showed the features of both an submucosal tumor and an e...

Molecular Dynamics Simulation of Spontaneous Imbibition in Nanopores and Recovery of Asphaltenic Crude Oils Using Surfactants for EOR Applications — We present Molecular Dynamics (MD) simulations of the imbibition process in nanopores in case of two different mechanisms of the wettability modification. We compare the imbibition of an aqueous surfactant solution into an oil-wet pore driven by su...