One of the most studied nanocarriers for drug delivery are polyamidoamine (PAMAM) dendrimers. However, the alterations produced by PAMAM dendrimers in neuronal function have not been thoroughly investigated, and important aspects such as effects on synaptic transmission remain unexplored. We focused on the neuronal activity disruption induced by dendrimers and the possibility to prevent these e...

The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conju...

Dendrimers are highly customizable nanopolymers with qualities that make them ideal for drug delivery. The high binding affinity of biotin/avidin provides a useful approach to fluorescently label synthesized dendrimer-conjugates in cells and tissues. In addition, biotin may facilitate delivery of dendrimers through the blood-brain barrier (BBB) via carrier-mediated endocytosis. The purpose of t...

Biomimetics, or the use of principles of Nature for developing new materials, is a paradigm that could help Nanomedicine tremendously. One of the current challenges in Nanomedicine is the rational design of new efficient and safer gene carriers. Poly(amidoamine) (PAMAM) dendrimers are a well-known class of nanoparticles, extensively used as non-viral nucleic acid carriers, due to their positive...

A nanoparticle drug carrier system has been developed to alter the cellular uptake and chemotherapeutic performance of an available chemotherapeutic drug. The system comprises of a multifunctional gold nanoparticle based drug delivery system (Au-PEG-PAMAM-DOX) as a novel platform for intracellular delivery of doxorubicin (DOX). Spherical gold nanoparticles were synthesized by a gold chloride re...

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

Background: Nanoscale poly (amidoamine) dendrimers have been investigated for their biological demands, but their antibacterial activity has not been widely discovered. Thus, the sixth generation of poly (amidoamine) dendrimer (PAMAM-G6) was synthesized and its antibacterial activities were evaluated on Gram-negative bacteria; P. aeruginosa, E. coli, A. baumannii, S. typhimurium, S. dysenteriae...

In this work, WO3 nanoparticle decorated magnetic poliamidoamin (PAMAM) dendrimer nanocomposites were fabricated and used as a catalyser for the reduction of 4-nitrophenol (4-NP). Fe3O4 superparamagnetic iron oxide nanoparticles core. Magnetic produced using hydrothermal synthesis. core was covered with PAMAM dendrimers. The dendrimers in covering process 2nd generation which proposed to protec...

Various cationic polypeptides of linear or highly branched structures were synthesized by introducing tertiary or quaternary ammonium groups and hydroxyl groups to poly(L-lysine) (PL) or polyamideamine (PAMAM) dendrimers. These polycations were mixed with plasmid DNA to form polyplexes and subjected to in vitro gene introduction experiment. The transient gene expression was greatly affected by ...

This study reveals novel mechanisms and potential biomarkers of nanopolymer toxicity (polystyrene nanoplastics PAMAM dendrimers) singly in combination a relevant aquatic primary producer, essential for sustaining the food chain.