Sarcoma 37 cells grew more rapidly in castrated male mice than in controls of the same genotype; however, this effect of castration was dependent on the host genotype. Among inbred YS/Wf mice, tumor weight was increased only in castrated yellow Ay/a males and not in the comparable black a/a males. In contrast, mean tumor weight was increased in both yellow Avy/a and black a/a castrated males of...

Title: Oral intake of Phenylbutyrate and vitamin D3 upregulates the Cathelicidin LL-37 in human macrophages: A dose finding study for treatment of tuberculosis Authors: Akhirunnesa Mily ([email protected]) Rokeya Sultana Rekha ([email protected]) SM Mostafa Kamal ([email protected]) Evana Akhtar ([email protected]) Protim Sarker ([email protected]) Zeaur Rahim ([email protected]) Gudmund...

In the course of our chemical screening program for new secondary metabolites, we isolated new compounds JBIR-37 (1) and -38 (2) from a culture broth of the marine sponge-derived fungus, Acremonium sp. SpF080624G1f01. The structures of 1 and 2 were determined to be di- and mono-O-beta-D-glucopyranosyloxy-4-(1,1-dimethyl-2-propenyl)benzene on the basis of extensive NMR and MS spectroscopic data,...

Here we show that keratinocytes in psoriatic lesional skin express increased Toll-like receptor (TLR) 9 that similarly localizes with elevated expression of the cathelicidin antimicrobial peptide LL-37. In culture, normal human keratinocytes exposed to LL-37 increased TLR9 expression. Furthermore, when keratinocytes were exposed to LL-37 and subsequently treated with TLR9 ligands, such as CpG o...

Antimicrobial peptide IG-25 (a truncated version of LL-37 of the cathelicidin family) tethering an azido-capped poly(ethylene glycol) chain at the N-terminus was site-specifically attached to alkynyl-terminated polymerized liposomes using copper catalyzed "click" reaction, leading to an 18 fold enhancement in efficacy against Pseudomonas aeruginosa when compared to LL-37 without any increase in...