Since the discovery of penicillin, bacteria have counteracted the action of antibiotics leading to a worrisome situation about antibiotic efficiency. During our research on non-traditional 1,3-bridged b-lactams embedded into macrocycles as potential inhibitors of Penicillin Binding Proteins (PBPs), we unexpectedly synthesized bis-2-oxoazetidinyl macrocycles arising from a dimerization reaction ...

O(N) algorithms for N{body simulations enable the simulation of particle systems with up to 100 million particles on current Massively Parallel Processors (MPPs). Our optimization techniques mainly focus on minimizing the data movement through careful management of the data distribution and the data references, both between the memories of diierent nodes, and within the memory hierarchy of each...

As global climate warms and sea level rises, coastal areas will be subject to more frequent extreme flooding and hurricanes. Geologic evidence for extreme coastal storms during past warm periods has the potential to provide fundamental insights into their future intensity. Recent studies argue that during the Last Interglacial (MIS 5e, ∼128-116 ka) tropical and extratropical North Atlantic cycl...

We evaluated the inhibitory effect of 12 Chinese teas on leukocyte-type 12-lipoxygenase (LOX) activity. Tea catechins such as epigallocatechin gallate have been known to exhibit leukocyte-type 12-LOX inhibition. Qing Shan Lu Shui, which contains lower catechin levels than the other tested teas, suppressed leukocyte-type 12-LOX activity. To characterize the bioactive components of Qing Shan Lu S...

Although gene-environment correlation is recognized and investigated by family studies and recently by SNP-heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective factors has been neglected by polygenic prediction models. We investigated covariation between trait-associated polygenic variation identified by genome-wide association st...

شرایط افروزش و اشتعال سوخت‌های گداخت هسته‌ای در حضور ناخالص­‌ها، یکی از موارد مهمی است که طراحی قرص‌های سوخت باید مورد توجه قرار گیرد. این مقاله اثر ناخالصی هسته سنگین طلا بر کلیه فرایندهای احتراق پلاسمای غیرتعادلی دوتریم- تریتیم مدل چهار دمایی آن شکل تابع توزیع انرژی رفتار فوتون‌ها تأثیر می‌گذارد بررسی گرفته است. مطالعه شامل اثرات منفی سوخت، طول زمان تشکیل لکه داغ نتایج محاسبات عددی به­ دست آم...

This paper presents a detailed empirical study of local search for Boolean satisfiability (SAT), highlighting several interesting properties, some of which were previously unknown or had only anecdotal evidence. Specifically, we study hard random 3-CNF formulas and provide surprisingly simple analytical fits for the optimal (static) noise level and the runtime at optimal noise, as a function of...

هدف: هدف از پژوهش حاضر، شناسایی مؤلفه‌های آزردگی‌های روانی انتقال‌یافته والدین به فرزندان، مبتنی بر مرور زندگی بود. روش: حاضر لحاظ روش‌شناسی نوع کیفی و روش نظریه داده بنیاد ‏و طریق نمونه‌گیری هدفمند نظری صورت گرفته است. جامعة موردپژوهش بین (پدر یا مادر) 35 تا 50 سال دارای فرزند نوجوان (دختر پسر در بازة سنی 13 18 سال) شهر تهران انتخاب شدند که به‌صورت داوطلبانه مصاحبه حضور پیدا کردند. با استفاده ...