Adriamycin (ADM) was chemically coupled to two monoclonal anti bodies (MAb) expressed on human B-cell lymphomas. Immunoconju gates were prepared by linking to the MAb an ADM derivative, Adria mycin 13-|3-(2-pyridy)dithio)propionyl]hydrazone (ADM-HZN), which releases ADM under mild acidic conditions (see preceding article). The (ADM-HZN) conjugates were tested for antitumor activity on two human...

Cells in the pancreas that have undergone acinar-ductal metaplasia (ADM) can transform into premalignant cells that can eventually become cancerous. Although the epithelial-mesenchymal transition regulator Snail (Snai1) can cooperate with Kras in acinar cells to enhance ADM development, the contribution of Snail-related protein Slug (Snai2) to ADM development is not known. Thus, transgenic mice...

The aim of the present study was to determine the effect of the combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and adriamycin (ADM) on the human breast cancer cell line MCF-7 and to identify potential mechanisms of apoptosis. Cell viability was analyzed by the MTT assay and the synergistic effect was assessed by the Webb coefficient. Apoptosis was quantified usin...

BACKGROUND Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM applica...

Cotransfer of angiogenic and antiapoptotic genes could be the basis of new gene therapy strategies for myocardial infarction. In this study, rAAV-PR39-ADM, coexpressing antimicrobial peptide (PR39) and adrenomedullin (ADM), was designed with the mediation of recombinant adeno-associated virus. In vitro, CRL-1730 cells were divided into four groups, namely, the sham group, the AAV-null group, th...

Associate Editors Arti Bhan, MD John E. Brunner, MD Stephen Brunton, MD Robert J. Chilton, DO, FACC Joseph Largay, PAC, CDE Gayle M. Lorenzi, RN, CDE Melinda Downie Maryniuk, MEd, RD, CDE, FADA Heather Remtema, MPH, RD, CCRP Editorial Board Leslie Barrett, MS, RD, CDE Nisha Basu, MD, MPH Christine Beebe, MS Nathaniel G. Clark, MD, MS, RD Kelly Close, BA, MBA Nancy J. D’Hondt, RPh, CDE, FAADE Ru...

In this study, we explored the function and mechanism of CDKN2B genes in verapamil (VER)-induced reversal of resistance to doxorubicin (ADM) chemotherapy in hepatocellular carcinoma (HCC). We examined 4 HCC cell lines and found that the expression levels of CDKN2B genes correlated with the level of apoptosis induced by ADM+VER. Overexpression of CDKN2B genes promoted apoptosis in cells treated ...

BACKGROUND Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. PATIENTS AND METHODS To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients w...

Antisynthetase (AS) syndrome is a major subgroup of inflammatory myopathies seen in a minority of patients with dermatomyositis and polymyositis. Although it is usually associated with elevated creatine phosphokinase level, some patients may have amyopathic dermatomyositis (ADM) like presentation with predominant skin involvement. Interstitial lung disease (ILD) is the main pulmonary manifestat...

The use of acellular dermal matrices (ADM) for dural repair is very scantily described in the literature. We report two cases of dural repair using porcine ADM and a literature review. ADM and especially StratticeTM pliable may be a useful alternative to other dural substitutes. Further evaluation would be favorable.