BACKGROUND This study was aimed to identify possible intracellular effectors of the somatostatin (SST) antiproliferative activity, in PCCl3 thyroid cells. METHODS To prove the involvement of r-PTPeta in SST's effect, we studied th proliferative activity of subclones of PCCl3 cells that do or do not express this PTP. RESULTS SST inhibited PCCl3 TSH+insulin-dependent cell proliferation throug...

The tropical Indian Ocean has experienced a faster warming rate in the west than in the east over the twentieth century. The warming pattern resembles a positive IndianOcean dipole (IOD) that is well captured by climate models from phase 5 of the CoupledModel Intercomparison Project (CMIP5), forced with the two main anthropogenic forcings, long-lived greenhouse gases (GHGs), and aerosols. Howev...

Sea surface temperature (SST) records are subject to potential biases due to changing instrumentation and measurement practices. Significant differences exist between commonly used composite SST reconstructions from the National Oceanic and Atmospheric Administration's Extended Reconstruction Sea Surface Temperature (ERSST), the Hadley Centre SST data set (HadSST3), and the Japanese Meteorologi...

To investigate the effects of somatostatin (somatotropin release-inhibiting factor, SRIF) on the regulation of SST(2A) receptors in mammalian brain, we examined how blockade of SRIF release or stimulation by the SRIF analog [d-Trp(8)]-SRIF would affect the expression and cell surface availability of SST(2A) receptors in rat brain slices. First, we measured the intensity of SST(2A) immunoreactiv...

[1] An aquaplanet general circulation model is used to assess the sensitivity of intraseasonal variability to the pattern of sea surface temperature (SST) warming. Three warming patterns are used. Projected SST warming at the end of the 21st century from the Geophysical Fluid Dynamics Laboratory Climate Model 2.1 is one pattern, and zonally symmetric and globally uniform versions of this warmin...

To assess distributional shifts of species in response to recent warming, historical distribution records are the most requisite information. The surface seawater temperature (SST) of Kochi Prefecture, southwestern Japan on the western North Pacific, has significantly risen, being warmed by the Kuroshio Current. Past distributional records of subtidal canopy-forming seaweeds (Laminariales and F...

Social skill deficits are a pervasive and enduring feature of autism spectrum disorders (ASD). As such, social skills training (SST) should be a critical component of programming for youth with ASD. A number of SST strategies exist, including those employing social stories, video modeling interventions, social problem solving, pivotal response training, scripting procedures, computer-based inte...

[1] Decadal changes of El Niño-Southern Oscillation (ENSO) persistence barriers in various indices of sea surface temperature (SST) and ocean heat content (OHC) are examined in this study using observations and ocean data assimilation products for the period 1958–2001. It is found that the SST indices in the eastern and central equatorial Pacific exhibit very different decadal barrier variabili...

Based on a fully coupled, high-resolution regional climate model, this study analyzed three-dimensional temperature and momentum changes in the South China Sea (SCS) from 1970 to 2000, during which period the climate shifts from a decadal La Ni~ na-like condition (before 1976/1977) to a decadal El Ni~ no-like condition afterward. With a set of partially coupled experiments, sea surface temperat...

Corleto, Vito D., H. Christian Weber, and Robert T. Jensen. Expression of somatostatin receptor subtypes on guinea pig gastric and colonic smooth muscle cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G235–G244, 1999.—In vivo and in vitro studies have demonstrated that somatostatin can influence motility and smooth muscle contractility of the stomach and colon. Recent studies have...