The slow transit time of the colon in females with constipation is due to impairment of agonist-induced contraction. The impairment is associated with downregulation of G proteins that mediate contraction and upregulation of Gs proteins that mediate relaxation. These changes are caused by overexpression of progesterone (P4) receptors in the colon, rendering its muscle cells sensitive to physiol...

In women, during pregnancy, there is decreased motility of the gastrointestinal tract leading to a delay in gastric emptying and an increase in colonic transit time. Whether the rise in estradiol (E2) or progesterone (P4) is responsible for this effect is controversial. As the nitrergic component of the nonadrenergic, noncholinergic (NANC) nerves is responsible for modulating gastrointestinal m...

P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids across cell membranes. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and trafficking, cell signaling, blood coagulation, apoptosis, bile and cholesterol homeostasis, and neuronal cell survival. Some P4-ATPases...

Bursting dynamics of mappings is investigated in this paper. We first present stability analysis of the mappings’ equilibria with various parameters. Then for three mappings P, P̄, and ̂ P with different parameters, we study their powers P4, P̄6, and ̂ P4. We show that the mappings thus obtained are chaotic by giving a rigorous verification of existence of horseshoes in these mappings. Precisely, w...

A short-term treatment with estradiol-17 beta and progesterone induced mammary gland growth and lactogenesis in non-pregnant ewes. These events normally occur during the second half of pregnancy. In order to compare the hormonal environment during the treatment to that during pregnancy, the concentrations of total estrogens (TE), progesterone (P4), glucocorticoids (G) and prolactin (Prl) in the...

The objectives of this study were to determine the effects of dose of exogenous progesterone (P4) prior to artificial insemination on concentrations of 17p-estradiol (E,) and on conception rates in bovine females. Heifers (n = 100) and cows (n = 100) received P4-releasing intravaginal devices (PRIDs) to produce two different circulating concentrations of P4. All animals received a single PRID 1...

Software Defined Networking (SDN) has been a prominent technology in the last decade that increases networking programmability. The SDN philosophy decouples application, control, and data plane to increase network is an essential but unsolved component receives less attention than control application planes. Traditionally, uses fixed functions forward packets using limited number of protocols. ...

A comparison of P4 activations mediated by low-valent β-diketiminato (L) cobalt complexes is presented. The formal Co0 source [K2 (L3 Co)2 (μ2 :η1 ,η1 -N2 )] (1) reacts with P4 to form a mixture of the monoanionic complexes [K(thf)6 ][(L3 Co)2 (μ2 :η4 ,η4 -P4 )] (2) and [K(thf)6 ][(L3 Co)2 (μ2 :η3 ,η3 -P3 )] (3). The analogue CoI precursor [L3 Co(tol)] (4 a), however, selectively yields the cor...

This study was designed to determine whether leptin modulates growth hormone (GH)- and insulin like growth factor-I (IGF-I)-stimulated progesterone (P4) production by corpora lutea (CL). Luteal cells were recovered from early developing (ELP) and mature (MLP) corpora lutea and cultured in defined medium with various combinations of GH, IGF-I, and leptin (0-200 ng/ml). P4 concentrations in the m...