Expressive speech is intrinsically multi-dimensional. Each acoustic dimension has specific weights depending on the nature of the expressed affects. The quantity of expressive information carried by each dimension separately (using Praat algorithms), as well as the processing implied to carry it (global value vs. contour) has been perceptively measured for a set of natural mono-syllabic utteran...

Recently, it has been reported that longer expansions of the polyalanine tract of the ARX gene could cause an early infantile encephalopathy with suppression burst pattern and that the length of this repeat region could be related to the severity of the electroclinical picture. We describe the history of two male individuals, born from monozygotic twin sisters, with Ohtahara syndrome (OS) that ...

Civil engineering structures are often subjected to multidirectional actions such as earthquake ground motion, which lead to complex structural responses. The contributions from the latter multidirectional actions to the response are highly coupled, leading to a MIMO system identification problem. Compared with single-input, multiple-output (SIMO) system identification, MIMO problems are more c...

In this paper we consider the nite sample properties of least squares identi cation in a stochastic framework The problem we pose is How many data points are required to guarantee with high probability that the expected value of the quadratic identi cation criterion is close to its empirical mean value The sample sizes are obtained using risk minimisation theory which provides uniform probabili...

Epileptic encephalopathies comprise a heterogeneous group of severe infantile disorders for which the pathophysiological basis of epilepsy is inaccurately clarified by genotype-phenotype analysis. Because a deficit of GABA neurons has been found in some of these syndromes, notably in patients with X-linked lissencephaly with abnormal genitalia, epilepsy was suggested to result from an imbalance...

The complex interactions between vapour-liquid equilibrium, mass and energy transports and reaction kinetics in reactive distillation (RD) process have constituted serious computational challenges to its modelling and control. This is because large numbers of nonlinear differential algebraic equations are needed to represent the process when using first principle modelling approach. This work d...

This paper addresses the efficient implementation of highperformance signal-processing algorithms. In early stages of such designs many computation-intensive simulations may be necessary. This calls for hardware description formalisms targeted for efficient simulation (such as the programming language C). In current practice, other formalisms (such as VHDL) will often be used to map the design ...

Neuronal migration disorders are a clinically and genetically heterogeneous group of malformations of cortical development, frequently responsible for severe disability. Despite the increasing knowledge of the molecular mechanisms underlying this group of diseases, their genetic diagnosis remains unattainable in a high proportion of cases. Here, we present the results of 38 patients with lissen...

Abstract High-cycle fatigue failures of fan blade systems due to vibrational loads are great concern in the design aeroengines, where energy dissipation by relative frictional motion dovetail joints provides main damping mitigate vibrations. The performance such a can be enhanced suitable coatings. However, analysis and coated joint roots gas turbine blades computationally expensive strong cont...

A plastic nervous system requires the ability not only to acquire and store but also to forget. Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans. Tissue-specific rescue demonstrates that MSI-1 function is necessary in the AVA interneuron. Using RNA-binding protein immunoprecipitation (IP), we found that MSI-1 binds to mRNAs of three subunits of the ...