نتایج جستجو برای: مدل epm

تعداد نتایج: 121126  

Journal: :Hormones and Behavior 2011
Joyce Mendes-Gomes Tarciso Tadeu Miguel Vanessa Cristiane Santana Amaral Ricardo Luiz Nunes-de-Souza

It has been demonstrated that the exposure of rodents to the standard elevated plus-maze (sEPM: 2 open and 2 enclosed arms) elicits defensive behavioral reactions and antinociception and also activates the hypothalamo-pituitary-adrenal (HPA) axis. We have recently reported that EPM-induced antinociception is particularly observed when rats and mice are exposed to a totally open EPM (oEPM: 4 ope...

Journal: :Neuropharmacology 2012
Qian Li Tian Luo Xue Jiang Jing Wang

The aim of the present study is to test a hypothesis that 5-HT(1A) and 5-HT(2C) receptors in the amygdala play an important role in the regulation of anxiety behaviors. We examined alterations in anxiety-like behaviors after manipulation of the expression of 5-HT(1A) and 5-HT(2C) receptors in the amygdala using recombinant adenovirus approaches. Recombinant adenoviruses containing a 5-HT(1A) pr...

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Allison T Knoll Edward G Meloni James B Thomas F Ivy Carroll William A Carlezon

Endogenous opioid systems regulate neurobiological responses to threatening stimuli. Stimulation of kappa-opioid receptors (KORs) produces analgesia but induces prodepressive-like effects in a variety of animal models. In contrast, KOR antagonists have antidepressant-like effects. KORs and their endogenous ligand dynorphin are expressed throughout brain areas involved in fear and anxiety, inclu...

Journal: :Life sciences 2011
Ulrike Gimsa Ellen Kanitz Winfried Otten Caroline Aheng Margret Tuchscherer Daniel Ricquier Bruno Miroux Saleh M Ibrahim

AIMS Uncoupling protein 2 (UCP2) is a mitochondrial protein that reduces oxidative stress and has a protective function in chronic inflammatory diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. UCP2 is strongly expressed in areas implicated in the central regulation of stress and anxiety. Therefore, we compared the neuroendocrine regulation of stress re...

2014
A.C.L. Gianlorenço K.R. Serafim A. Canto-de-Souza R. Mattioli

This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM). The cerebellar vermis of male mice (Swiss albino) was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2). Immediately after exposure to the EPM (T1...

2018
Toya Okonogi Ryota Nakayama Takuya Sasaki Yuji Ikegaya

Citation: Okonogi T, Nakayama R, Sasaki T and Ikegaya Y (2018) Characterization of Peripheral Activity States and Cortical Local Field Potentials of Mice in an Elevated Plus Maze Test. Front. Behav. Neurosci. 12:62. doi: 10.3389/fnbeh.2018.00062 Elevated plus maze (EPM) tests have been used to assess animal anxiety levels. Little information is known regarding how physiological activity pattern...

2015
Zahra Nemati Samaneh Oveisi Alireza Komaki Siamak Shahidi

Background: There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives: The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. Materials and Methods: Male Wistar...

2004
E. Baron Peter E. Nugent Peter H. Hauschildt

Due to their intrinsic brightness, supernovae make excellent cosmological probes. We describe the SEAM method for obtaining distances to Type IIP supernovae (SNe IIP) and present a distance to SN 1999em for which a Cepheid distance exists. Our models give results consistent with the Cepheid distance, even though we have not attempted to tune the underlying hydrodynamical model, we have simply c...

2015
Diana Limburg Cathy Knowles Maureen McCulloch

Charities are often complex and networked, and face an increasingly demanding environment. Providing stakeholders with timely and adequate information on activities and impact is therefore challenging. Based on case studies of six UK charities, this paper finds that small/medium charities can use Enterprise Performance (EPM) systems to support providing such information, despite some challenges...

2015
Siobhan P Ellison Tom J Kennedy Austin Li

Polyneuritis equi is an immune-mediated neurodegenerative condition in horses that is related to circulating demyelinating antibodies against equine myelin basic protein 2 (MP2). The present study examined the presence of circulating demyelinating antibodies against neuritogenic peptides of MP2 in sera from horses suspected of equine protozoal encephalomyelitis (EPM), a neurodegenerative condit...

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