The intensity dependence of the local and remote effects of transcranial magnetic stimulation (TMS) on human motor cortex was characterized using positron-emission tomography (PET) measurements of regional blood flow (BF) and concurrent electromyographic (EMG) measurements of the motor-evoked potential (MEP). Twelve normal volunteers were studied by applying 3 Hz TMS to the hand region of prima...

Isoprenoids are a large family of compounds with essential functions in all domains of life. Most eubacteria synthesize their isoprenoids using the methylerythritol 4-phosphate (MEP) pathway, whereas a minority uses the unrelated mevalonate pathway and only a few have both. Interestingly, Brucella abortus and some other bacteria that only use the MEP pathway lack deoxyxylulose 5-phosphate (DXP)...

BACKGROUND Duchenne muscular dystrophy (DMD) is a rare, degenerative, X-linked genetic disease that results in progressive muscle loss and premature death, most commonly from respiratory or cardiac failure. DMD is primarily caused by whole exon deletions, resulting in a shift of the dystrophin mRNA reading frame that prevents production of functional dystrophin protein. Eteplirsen, a phosphorod...

BACKGROUND AND PURPOSE The early prognostic application of transcranial magnetic brain stimulation (TMS) for assessing motor and functional recovery in ischemic stroke patients has yielded contradictory results. We performed a prospective study of patients with acute ischemic stroke and motor deficit to evaluate the early prognostic value of TMS in motor and functional recovery. METHODS Fifty...

Quantized maximum a posteriori (Q-MAP) is a recently-proposed Bayesian compressed sensing algorithm that, given the source distribution, recovers X from its linear measurements Y m = AX, where A ∈ R denotes the known measurement matrix. On the other hand, Lagrangian minimum entropy pursuit (L-MEP) is a universal compressed sensing algorithm that aims at recovering X from its linear measurements...

A pesticide runoff event was simulated on two 10 m x 50 m constructed wetlands (one non-vegetated, one vegetated) to evaluate the fate of methyl parathion (MeP) (Penncap-M). Water, sediment, and plant samples were collected at five sites downstream of the inflow for 120 d. Semi-permeable membrane devices (SPMDs) were deployed at each wetland outflow to determine exiting pesticide load. MeP was ...

Background: Recently, we reported a new technique to augment motor evoked potentials (MEPs) under general anesthesia, called as post-tetanic MEP (p-MEP), in which tetanic stimulation of peripheral nerve prior to transcranial stimulation enlarged amplitudes of MEPs from the muscle innervated by the nerve subjected to tetanic stimulation. In the present study, we tested whether tetanic stimulatio...

Carotenoids and chlorophylls are photosynthetic pigments synthesized in plastids from metabolic precursors provided by the methylerythritol 4-phosphate (MEP) pathway. The first two steps in the MEP pathway are catalyzed by the deoxyxylulose 5-phosphate synthase (DXS) and reductoisomerase (DXR) enzymes. While DXS has been recently shown to be the main flux-controlling step of the MEP pathway, bo...

The understanding of the effects multidirectional loadings imposed on major load bearing elements such as reinforced concrete (RC) columns by seismic actions for collapse prevention is utmost importance, and a few simplified models are available in literature. In this study, distinguishing features two machine-learning (ML) methods, namely, multi expression programming (MEP) adaptive neuro-fuzz...