HM-3, designed by our laboratory, is a polypeptide composed of 18 amino acids. Pharmacodynamic studies in vivo and in vitro indicated that HM-3 could inhibit endothelial cell migration and angiogenesis, thereby inhibiting tumor growth. However, the half-life of HM-3 is short. In this study, we modified HM-3 with different polyethylene glycols (PEG) in order to reduce the plasma clearance rate, ...

A new class of methoxy-poly(ethylene glycol) (mPEG) derivatives having a cleavable group of oligo-lactic acid (OLA) was synthesized by ring opening polymerization of L-lactide using a terminal hydroxyl end of mPEG as an initiator. The synthesized mPEG derivatives had 0.8 and 3.6 lactic acid units based on the MALDI-TOF data. A terminal end group of mPEG-OLA was further activated with p-nitrophe...

MPEG Spectral Band Replication (SBR) is the newest compression technology available as part of the MPEG standards. It is combined with MPEG Advanced Audio Coding (AAC) and improves coding efficiency by more than 30%. The resulting scheme is called High-Efficiency AAC (HE AAC). This presentation explains MPEG SBR and its integration into the existing MPEG-4 bitstream format. The SBR technology i...

T he advent of object-based multime-dia standards, in particular MPEG-4, has brought new challenges to the subject of media streaming over the Internet. To tackle these challenges, the Moving Picture Expert Group (MPEG) defined a generic multimedia delivery platform—the Delivery Multimedia Integration Framework—under the MPEG-4 umbrella. In this article we describe the DMIF framework and examin...