Influenza A virus poses serious health threat to humans. Neutralizing antibodies against the highly conserved M2 ion channel is thought to offer broad protection against influenza A viruses. Here, we screened synthetic Camel single-domain antibody (VHH) libraries against native M2 ion channel protein. One of the isolated VHHs, M2-7A, specifically bound to M2-expressed cell membrane as well as i...

A graph G is called randomly H − decomposable if every maximal H − packing in G uses all edges in G. G is called H − equipackable if every maximal H − packing in G is also a maximum H − packing in G. M2 − decomposable graphs, randomly M2 − decomposable graphs and M2 − equipackable graphs have been characterized. The definitions could be generalized to multigraphs. And M2 − decomposable multigra...

Let m2 denote the infinite dimensional N-graded Lie algebra defined by the basis ei for i ≥ 1 and by relations [e1, ei] = ei+1 for all i ≥ 2, [e2, ej ] = ej+2 for all j ≥ 3. We compute in this article the bracket structure on H(m2;m2), H (m2;m2) and in relation to this, we establish that there are only finitely many true deformations of m2 in each weight by constructing them explicitely. It tur...

Results The point prevalence of AD in our cohort was 18.7% (299/1597) at 6 months and 15.52% (232/1494) at 12 months. TEWL was lowest at birth, with mean reading 7.32 gwater/m2/hr (±3.33 gwater/m2/hr). It rose between birth and 2 months, mean 10.97 gwater/m2/hr (±7.98 gwater/m2/hr) where it plateaued at 6 months with mean reading 10.71 gwater/m2/hr (±7.10 gwater/ m2/hr). A raised TEWL at 2 mont...

به دلیل عدم قطعیت‌های شناختی، تصادفی و محدودیت‌های انعطاف پذیر، در این مطالعه مدل جدیدی از برنامه‌ریزی محدودیت شانس انعطاف‌پذیر، امکانی، استوار مختلط بر مبنای تئوری اعتبار برای طراحی شبکه زنجیره تامین حلقه بسته توسعه داده شد. نگرش‌های متفاوت تصمیم‌گیرندگان با اندازه‌گیری انعطاف‌پذیرتر پارامترهای خوش‌بینانه بدبینانه قالب معیار پاسخ حداقل سطح رضایت انعطاف‌پذیر حل بهینه گردید. پیشنهادی، قادر کاهش ...

BACKGROUND AND METHODS Icodextrin 7.5% is an iso-osmolar, glucose polymer-containing peritoneal dialysis solution with an ultrafiltration potential similar to glucose 3.86%. We compared in an open, randomized, prospective study the ultrafiltration potential of icodextrin with that of glucose during the daytime dwell of 23 patients treated with automated peritoneal dialysis (CCPD). RESULTS Day...