The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 6 989–1007 www.jcb.org/cgi/doi/10.1083/jcb.201309022 JCB 989 Correspondence to Gero Steinberg: [email protected] A. Berepiki’s present address is The James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK. Abbreviations used in this paper: CC, coiled coil; EE, early endosome; FHIP, FTSand Hook-interacting prote...

This paper deals with Expert Systems (ES) development as the final product of a Software Product Line. (SPL). We take into account software variability management in the ES domain. Two kinds of variability emerge: variability in the behavior as well as in the structure of such systems. Experts' knowledge is captured using domain conceptual models in order to manage the variability and functiona...

Neutrophil (PMNL) function is influenced by factors released by other immune cells during the course of the immune response. We investigated the effect of neutrophil cell density and the effect of supernatant of the phagocytosis assay on the phagocytosis activity of PMNLs. The measurements were carried out with naive (control) PMNLs of healthy donors and with PMNLs obtained from patients with s...

We are given n data points x1, . . . , xn and some way to compute similarities between them, call si,j the similarity between the n points. Assume that the similarity function is symmetric, so si,j = sj,i. For the purposes of this lecture let us just consider the simplified clustering problem where we would like to split the dataset into two clusters. We would like to find a subset S ⊂ [n] of s...

The wearable artificial kidney (WAK) is a device that allows prolonged and frequent dialysis treatments for patients with end stage renal disease. It potentially provides a practical and feasible solution to satisfy the need for an optimal delivered dialysis. Until now, the WAK has already been presented in several models, proposing different therapeutic modalities and engineering approaches. T...