Live attenuated measles virus (MV-Edm) has potent oncolytic activity against myeloma xenografts in mice. Therapy of multiple myeloma, a disseminated plasma cell malignancy, would require systemic administration of the virus. Thus, the virus should ideally be targeted to infect only myeloma cells to minimize collateral damage to normal tissues: viral binding to its natural receptors must be abla...

Harnessing information technology to manage documents is one of the most important challenges facing IS managers in this decade. It is important because most of the valuable information in organizations is in the form of documents such as business forms, reports, letters, memos, policy statements, contracts, agreements, etc. Moreover, most of the important business processes in organizations ar...

Supersymmetric contributions to the neutron electric dipole moment (EDM) are studied taking account of the flavor changing interactions. We found that the gluino contribution is sensitive to the flavor changing interaction. Enhancement of neutron EDM via flavor mixing effects is possible when the squark mass difference between the different generations is sizable. As an example, the results of ...

Electroconductive, homogeneous and dense ceramic/semiconductor/metal nanocomposites were obtained by hot press and subsequently machined by wire Electrical Discharge Machining (EDM). The addition of semiconductor and metal phases to a highperformance ceramic material produces nanocomposites which preserve the excellent mechanical properties of the ceramic/metal material while reaching the elect...

One of the challenging problems in collaborative position localization arises when the distance measurements contain Non-Line-Of-Sight (NLOS) biases. Convex optimization has played a major role in modelling such problems and numerical algorithm developments. One of the successful examples is the Semi-Definite Programming (SDP), which translates Euclidean distances into the constraints of positi...

This paper describes algorithms and software for decomposing CAD models for a new mold manufacturing process called WirePATHe, which uses wire electrical discharge machining (EDM) to reduce mold fabrication time. A decomposition strategy has been developed to account for the limitations of wire EDM. During decomposition, CAD models are separated into manufacturable segments and then layered if ...

Surface roughness is the main indicator of technological performances of a component for electrical discharge machining (EDM). EDM process of manganese alloyed cold-work tool steel was modelled. In this paper we used the fuzzy logic (FL) and neural network (NN) to predict the effect of machining variables (discharge current and pulse duration) on the surface roughness of manganese alloyed cold-...

The performance of electrical discharge machining (EDM) is dependent on the selection of factor/levels combinations of input parameters. The optimization of EDM process is a multi-objective optimization problem on account of the contradictory behaviour of performance measures like metal removal rate and surface roughness (MRR, SR). Many optimization technique are used for the parametric optimiz...

Euclidean distance embedding appears in many high-profile applications including wireless sensor network localization, where not all pairwise distances among sensors are known or accurate. The classical Multi-Dimensional Scaling (cMDS) generally works well when the partial or contaminated Euclidean Distance Matrix (EDM) is close to the true EDM, but otherwise performs poorly. A natural step pre...