Degeneration of skeletal muscle (SkM) with age (sarcopenia) is a major contributor to functional decline, morbidity and mortality. Methodological implications often make it difficult to embark on interventions in already frail and diseased elderly individuals. Using in vitro three-dimensional (3D) bioengineered skeletal muscle constructs that model aged phenotypes and incorporate a representati...

A persistent problem hampering our understanding of the dynamics of large-scale metabolic networks is the lack of experimentally determined kinetic parameters that are necessary to build computational models of biochemical processes. To overcome some of the limitations imposed by absent or incomplete kinetic data, structural kinetic modeling (SKM) was proposed recently as an intermediate approa...

We hypothesized that ablation of smooth muscle α-actin (SM α-A), a contractile-cytoskeletal protein expressed in airway smooth muscle (ASM) cells, abolishes ASM shortening capacity and decreases lung stiffness. In both SM α-A knockout and wild-type (WT) mice, airway resistance (Raw) determined by the forced oscillation technique rose in response to intravenous methacholine (Mch). However, the s...

The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better unde...

Salah satu cara meningkatkan kualitas sumber daya manusa pegawai negeri sipil adalah mengikuti diklat teknis yang dirancang untuk memenuhi kompetensi dibutuhkan dalam rangka pengembangan profesionalisme dan peningkatan mutu pelaksanaan tugas umum pelayanan di pemerintah. Penelitian ini bertujuan mengevaluasi aspek mempengaruhi tingkat optimalisasi penyelenggaran PPSDM Geominerba. Metode penelit...