We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Importantly, SZ-179 reduced the proteolysis of VWF-R1597W mutant by rADAMTS13 dose-dependently under native co...

Mitochondrial deficiencies with unknown causes have been observed in schizophrenia (SZ) and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic mutations in mitochondrial DNA (mtDNA) were investigated as potential causes with next generation sequencing of mtDNA (mtDNA-Seq) and genotyping arrays in subjects with SZ, BD, major depressive disorder (MDD), and controls...

It is unresolved whether avoidant personality disorder (APD) is an independent schizophrenia (Sz)-spectrum personality disorder (PD). Some studies find APD and social anxiety symptoms (Sxs) to be separable dimensions of psychopathology in relatives (Rels) of schizophrenics while other studies find avoidant Sxs to be correlated with schizotypal and paranoid Sxs. Rates of APD among first-degree R...

Near-future SZ surveys such as ACT, SPT, APEX, and Planck will soon find thousands of galaxy clusters. Multi-frequency arcminute-resolution SZ observations can, in principle, determine each cluster’s gas temperature (Te), bulk velocity (vpec), and optical depth (τ). However, the frequency bands and detector sensitivity employed by upcoming surveys will generally not be sufficient to disentangle...

Mice injected with multiple low dose of streptozotocin (mld-SZ) or transferred with mononuclear splenocytes (MS) from mld-SZ donors constitute animal models that allow the study of autoimmune diabetes. Mld-SZ mice show a progressive beta-cell destruction iniciated during non-specific islet inflammation involving free radicals as nitric oxide (NO°). Pharmacological inhibitors of NO° synthase del...

A cardinal related to compositions of Sierpiński–Zygmund functions from the left, cleft(SZ), will be considered. We answer a question of K. Ciesielski and T. Natkaniec. In particular, we show that cl(SZ) = (2c)+ if R is not a union of less than c-many meager sets and c is a limit cardinal. If c = ω1, then cl(SZ) is equal to the bounding number of c.

<p style='text-indent:20px;'>The goal of the present manuscript is to introduce a new sequence linear positive operators, i.e., Sz<inline-formula><tex-math id="M2">\begin{document}$ \acute{a} $\end{document}</tex-math></inline-formula>sz-Schurer-Beta type operators approximate class Lebesgue integrable functions. Moreover, we calculate basic estimates and central m...

Emerging evidence points to proteoglycan abnormalities in the pathophysiology of schizophrenia (SZ). In particular, markedly abnormal expression of chondroitin sulfate proteoglycans (CSPGs), key components of the extracellular matrix, was observed in the medial temporal lobe. CSPG functions, including regulation of neuronal differentiation and migration, are highly relevant to the pathophysiolo...

Lymphoblastoid cell lines (LCLs) and fibroblasts provide conveniently derived non-neuronal samples in which to investigate the aetiology of schizophrenia (SZ) using gene expression profiling. This assumes that heritable mechanisms associated with risk of SZ have systemic effects and result in changes to gene expression in all tissues. The broad aim of this and other similar studies is that comp...

Recent research suggests that the cerebral correlates of cognitive deficits in schizophrenia are nested in the activity of widespread, inter-regional networks rather than being restricted to any specific brain location. One of the networks that have received focus lately is the default mode network. Parts of this network have been reported as hyper-activated in schizophrenia patients (SZ) durin...