G12/13 or Gq signaling pathways activate platelet GPIIb/IIIa when combined with Gi signaling. We tested whether combined Gi and Gz pathways also cause GPIIb/IIIa activation and compared the signaling requirements of these events. Platelet aggregation occurred by combined stimulation of Gi and Gz pathways in human platelets and in P2Y1-deficient and G qdeficient mouse platelets, confirming that ...

BACKGROUND/AIMS While chemoradiotherapy (CRT) is considered to be a reasonable treatment for locally advanced pancreatic cancer (LAPC), there is little information about the associated risk of gastrointestinal (GI) hemorrhage. We investigated the clinical features of GI toxicity after CRT in patients with LAPC and examined the effect of GI hemorrhage on survival. METHODS Patients enrolled in ...

OBJECTIVE Chronic granulomatous disease (CGD) is a rare disorder of phagocyte oxidative metabolism. In addition to infectious complications, granulomatous lesions often involve hollow viscera, especially the gastrointestinal (GI) tract. The objective of this study was to evaluate the clinical presentation, prevalence, and consequences of GI involvement in patients with CGD. METHODS The medica...

The aim of this study was to investigate the effect of Cystamine (CYS) on the hippocampal CA1 region in rats with whole cerebral ischemia. A total of 104 adult male Sprague-Dawley rats were prepared using the modified Pulsinelli method for a global Cerebral Ischemia (GI) model, and then randomly divided into a sham group (S, n=8), a GI group (GI, n=48), and a GI+CYS group (GI+CYS, n=48). The la...

The metabolic and performance benefits of prior consumption of low-glycaemic index (GI) meals v. high-GI meals were determined in extended high-intensity intermittent exercise. Participants (ten males and four females, aged 25·8 (sd 7·3) years) completed two testing days (each consisting of back-to-back 90-min intermittent high-intensity treadmill running protocols separated by 3 h) spaced by a...

Integrating information about the glycaemic index (GI) of foods into the Caribbean diet is limited by the lack of data. Therefore, we determined the GI of eight staple foods eaten in the Caribbean and the effect on GI of crushing selected tubers. Groups of eight to ten healthy volunteers participated in three studies at two sites. GI was determined using a standard method with white bread and a...

We report here the first complete genome sequences of genotype GI.3, GI.4, GI.6, GI.7, and GII.7 sapovirus strains, detected from fecal samples of acute gastroenteritis patients. Complete or nearly complete genome sequences of all 18 genotypes of human sapoviruses are now available for phylogenetic analysis and primer design.

The expression of guanine nucleotide-binding protein (G-protein) genes (Gs alpha, Go alpha, Gi alpha 1, Gi alpha 2, and Gi alpha 3) was examined in the ventricle of cardiomyopathic Syrian hamsters of the Bio14.6 strain (10-35 weeks old). Northern blot analysis of total cellular RNA revealed that all G-protein genes except Gi alpha 1 were expressed in the ventricle of Syrian hamsters. Gs alpha a...

This work presents a prototype implementation of a smartphone as secure eID reader using NFC technology. The presented approach aims to reach a security level close to standalone smart card readers. This security level will be allowed by the means of a trusted execution environment (TEE) which allows strong isolation and separation for critical applications and provides trusted, not interceptab...

The regulations of the European Union (EU) Council in 2004 are the basis of the deployment of electronic passports within the EU. Since then EU member states adopt the format and the access protocols to further electronic machine readable travel documents (eMRTD) like national electronic ID cards and electronic residence permits, respectively. The security protocols to communicate with an eMRTD...