Oxidative stress in the vascular wall has intimately been implicated in the apoptosis of human umbilical vein endothelial cells (HUVECs) by lysophosphatidylcholine (LPC). However, the major type of reactive oxygen species (ROS) in this apoptotic signaling pathway remains to be clarified. In this study, we report that superoxide mediate LPC-induced caspase-3 dependent apoptosis in cultured HUVEC...

Traditional sequential data analysis largely depends on the magnitude of the data with the geometric features of individual data points sometimes being regarded as noise to such analysis. To explore whether these geometric features alone carry some useful information for a better understanding of hidden facts contained in the sequential data, a new method called local position classification (L...

The radiation sensitivity of memory cells increases dramatically as CMOS manufacture technology scales down; therefore, the reliability memories has become a challenge. 3D gained attention for having several advantages compared to 2D counterpart, such high integration density, performance, low power, and communication speed. Although studies are targeting memories, effects on using this have re...

The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing studies show that LPCs differentiate into functional hepatocytes in this model. The CDE diet was first modified for mice by our laboratory by separ...

Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor signaling. Lysophosphatidylcholine (LPC), also known as lysolecithin, which is...

Recent studies suggested that endothelium is a main source of reactive oxygen species (ROS) and the major source was via NADPH oxidase pathway. Various stimuli including lysophosphatidylcholine (LPC), a major component of oxidized low-density lipoprotein (ox-LDL), can enhance the activity of NADPH oxidase and lead to a marked ROS generation. Asymmetric dimethylarginine (ADMA) is an endogenous n...

In cells, N-ethylmaleimide-sensitive factor (NSF) attachment protein receptors called SNAREs are involved in membrane fusion. In neurons, for example, target membrane proteins SNAP-25 and syntaxin called t-SNAREs present at the pre-synaptic membrane, and a synaptic vesicle-associated membrane protein (VAMP) or v-SNARE, is part of the conserved protein complex involved in neurotransmission. Chol...

The purpose of this study is to analyze whether the maturation of spontaneous EEG occurs at the same rate as Late Positive Component (LPC) maturation. To that end, the spontaneous EEG rhythms power spectral density (PSD) and the LPC component in a group of children and a group of young adults were obtained and analyzed by means of Spearman’s correlation coefficients, hierarchical clustering, Pr...

8 Last principal component (LPC) modeling relies on principal component transformation, and utilizes the eigenvectors associated 9 with the last (smallest) principal components. When applied to experimental data, it may be considered an alternative to least 10 squares based estimation of model parameters. Experimental results in the literature (cited in the body of the paper) suggest that 11 LP...

In the speaker recognition, when the cepstral coe cients are calculated from the LPC analysis parameters, the LPC residual and pitch are usually ignored. This paper describes an approach to integrate the pitch and LPC-residual with the LPC-cepstrum in a GaussianMixture Model based speaker recognition system. The pitch and LPC-residual are represented as a logarithm of the F0 and as a MFCC vecto...