The calcineurin inhibitor (CNI) tacrolimus (TAC) is an integral part of the immunosuppressive regimen after solid organ transplantation. Although TAC is very effective in prevention of acute rejection episodes, its highly variable pharmacokinetic and narrow therapeutic window require frequent monitoring of drug levels and dose adjustments. TAC can cause CNI nephrotoxicity even at low blood trou...

OBJECTIVE The purpose of the study was to assess total antioxidant capacity (TAC) of blood serum in relation with habitual leisure time physical activity (LTPA) and aerobic capacity in a group of 90 men with coronary heart disease (CHD) aged 34.8-77.0 years and in 90 age-matched peers without CHD. METHODS Two spectrophotometric methods were applied to assess TAC: Ferric Reducing Ability of Se...

We report the formation of highly-oriented B1-TaC(111) and rhombohedral-Ta3C2(0001) phases on Al2O3(0001) substrate during ultrahigh vacuum dc magnetron sputtering a TaC target in 5 mTorr Ar/C2H4 gas mixtures with 0.1% 1% ethylene partial pressures pc at temperatures Ts = 1123 K 1273 K. determined as-deposited layer morphology, crystallinity, microstructure, spatial compositional variation usin...

Tacrolimus (TAC) pharmacokinetics are characterized by a very high variability that complicates its therapeutic use. The aims of this study were: 1) to identify and model the effect of demographic, clinical, and genetic factors and time of drug administration on TAC pharmacokinetic variability; and 2) to assess the influence of the analytical method by modeling the TAC blood concentrations meas...

The Tac antigen component of the bovine interleukin-2 receptor was expressed as a Cro-beta-galactosidase fusion protein in Escherichia coli and used to raise antibodies in rabbits. These antibodies were used for flow cytofluorimetric analysis to investigate the expression of Tac antigen in a variety of Theileria parva-infected cell lines and also in three Theileria annulata-infected cell lines....

BACKGROUND Intramyocardial triglyceride (TG) turnover is reduced in pressure-overloaded, failing hearts, limiting the availability of this rich source of long-chain fatty acids for mitochondrial β-oxidation and nuclear receptor activation. This study explored 2 major dietary fats, palmitate and oleate, in supporting endogenous TG dynamics and peroxisome proliferator-activated receptor-α activat...

OBJECTIVE To compare outcomes with the use of thyroid ala cartilage (TAC) and costal cartilage (CC) grafts in pediatric primary anterior laryngotracheoplasty (LTP). DESIGN Retrospective comparison study. SETTING Tertiary, academic children's hospital. PATIENTS Of 45 laryngotracheal operations performed between June 2001 and October 2008 for laryngotracheal stenosis, 29 were primary anteri...

It is my pleasure to transmit to you the report of the TAC commissioned study on CGIAR Research and Poverty Reduction. The study was conducted by IFPRI in consultation with TAC with the aim of describing the processes and conditions under which agricultural technology can be an effective instrument for poverty reduction. The attached report was considered by TAC at its 81st meeting held in Bogo...

INTRODUCTION Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial ischemia in a pig model of chronic myocardial ischemia through enhanced myocardial angiogenesis. In the present study, we thus examined whether LIPUS also ameliorates contractile dysfun...