نتایج جستجو برای: ژن فاکتور ix
تعداد نتایج: 47058 فیلتر نتایج به سال:
Carbonic anhydrase IX is a hypoxia-induced transmembrane enzyme linked with solid tumors. It catalyzes the reversible hydration of CO2 providing bicarbonate ions for intracellular neutralization and protons for extracellular acidosis, thereby supporting tumor cell survival and invasiveness. CA IX is the only human CA isoform containing the proteoglycan (PG) domain in its extracellular part. The...
objective(s) sonodynamic therapy is a physical treatment which utilizes ultrasound waves with an appropriate sensitizer such as protoporphyrin ix (ppix). the activation of sensitizer depends on cavitation, and therefore, high intensity ultrasound is an important necessity. beside, high intensity ultrasound can induce side effects on the healthy tissues which have surrounded tumor. the particles...
In resting platelets, the GPIb-IX complex, the receptor for the von Willebrand factor (vWF), is linked to underlying actin filaments by actin-binding protein (ABP-280). Thrombin stimulation of human platelets leads to a decrease in the surface expression of the GPIb-IX complex, which is redistributed from the platelet surface into the open canalicular system (OCS). Because the centralization of...
Thrombosis and/or disseminated intravascular coagulation (DIC) are complications specifically associated with the use of factor IX complex in some patients. Assuming that these complications might result from zymogen overload, we have produced, using diethylaminoethyl (DEAE)-Sephadex (Pharmacia, Piscataway, NJ) and sulfated dextran chromatography, a factor IX concentrate (coagulation factor IX)...
آئروموناس هیدروفیلا عامل بیماری سپتی سمی هموراژیک در ماهیان آب شیرین مخصوصاً کپورماهیان می باشد. این باکتری تحت تاثیر چندین فاکتور، ایجاد بیماری می کند که مکانیسم های ایجاد بیماری توسط این باکتری ناشناخته است. ژن های حدت مهمترین فاکتور بیماریزایی در باکتری آئروموناس هیدروفیلا می باشند. در این مطالعه 30 جدایه باکتری با روش های بیوشیمیایی رایج و ردیابی ناحیه ژنی 16S rDNA از طریق PCR به عنوا...
An investigation of the behavior of protoporphyrin IX, deuteroporphyrin IX, haematoporphyrin IX and coproporphyrin III in aqueous solution revealed extensive and complex aggregation processes. Protoporphyrin appears to be highly aggregated under all conditions studied. At concentrations below 4 muM, aggregation of deutero-, haemato- and coproporphyrin is probably restricted to dimerization. At ...
PURPOSE Hypoxia is associated with malignant progression and poor outcome in several human tumors, including soft tissue sarcoma. Recent studies have suggested that carbonic anhydrase (CA) IX is an intrinsic marker of hypoxia, and that CA IX correlates with poor prognosis in several types of carcinoma. The aim of this study was to quantify the extent of CA IX expression and to investigate wheth...
چکیده سابقه و هدف: فاکتور هفت، پروتئاز انعقادی مسئول شروع آبشار واکنش های پروتئولیتیک است که به تولید ترومبین و در نتیجه تشکیل لخته می انجامد. به دلیل به کارگیری موفق آن در کنترل هموفیلی و نقش احتمالی آن در فرآیندهای مختلف سلولی، فاکتور هفت به عنوان هدف ژن درمانی و سایر مشکلات بالینی مورد توجه قرار گرفته است. در این مطالعه، رده سلولی hepg2 برای کلون فاکتور vii مورد استفاده قرار گرفت. روش بررسی:...
Factor IX has been expressed to high levels within a recombinant host cell and the biologically active fraction subsequently purified to homogeneity for characterization. The coding sequence for Factor IX was inserted into a mammalian cell expression vector and transfected into dihydrofolate reductase-deficient Chinese hamster ovary cells. The integrated DNA was amplified to a high copy number ...
The conformation of the A1 domain of von Willebrand factor (vWF) is a critical determinant of its interaction with the glycoprotein (GP) Ib/V/IX complex. To better define the regulatory mechanisms of vWF A1 domain binding to the GPIb/V/IX complex, we studied vWF-dependent aggregation properties of a cell line overexpressing the GPIba, GPIbb, and GPIX subunits (CHO-GPIbab/IX cells). We found tha...
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