Alix/AIP1 regulates cell death in a way involving interactions with the calcium-binding protein ALG-2 and with proteins of ESCRT (endosomal sorting complex required for transport). Using mass spectrometry we identified caspase-8 among proteins co-immunoprecipitating with Alix in dying neurons. We next demonstrated that Alix and ALG-2 interact with pro-caspase-8 and that Alix forms a complex wit...

Given a pseudomonad $mathcal{T} $ on a $2$-category $mathfrak{B} $, if a right biadjoint $mathfrak{A}tomathfrak{B} $ has a lifting to the pseudoalgebras $mathfrak{A}tomathsf{Ps}textrm{-}mathcal{T}textrm{-}mathsf{Alg} $ then this lifting is also right biadjoint provided that $mathfrak{A} $ has codescent objects. In this paper, we give  general results on lifting of biadjoints. As a consequence, ...

A category is said to be alg-universal, if every category of universal algebras can be fully embedded into it. We prove here that the category of finitary endofunctors of the category Set is alg-universal. We also present an example of a proper class of accessible set functors with no natural transformations between them (except the obvious identities).

Bu çal??man?n amac?, Salda Gölü destinasyonunun marka de?erini ortaya ç?karmakt?r. Çal??ma, Eylül – Aral?k 2020 aylar? aras?nda destinasyonunu ziyaret eden ya da konaklayan gönüllü kat?l?mc?lara nicel olarak ve anket yoluyla yüz yüze yap?lm??t?r. Çal??maya toplamda 325 ki?i kat?lm??t?r. Kat?l?mc?lar?n Gölü’nün de?erine ili?kin alg?lamalar? tüm de?er bile?enlerinde ortan?n üzerindedir. genel de?...

Systems of Diierential-Algebraic Equations (DAE's) have been widely investigated, during the last twenty years, from a numerical point of view. The notion of index has shown to be eecient for the classiication of such systems with respect to the diiculties when trying to solve them with the standard discretization schemes. In this paper, our interest is in the study of formal (\structural") pro...

Amaç: Çal??ma kapsam?nda; çal??anlar?n kurumsal sosyal sorumluluk alg?s?n?n i? arkada?lar? çevre duyarl?l??? üzerindeki etkisini ortaya ç?karmay? amaçlam??t?r. Yöntem/Tasar?m/Metodoloji/Yakla??m: kapsam?nda kullan?lan veriler, Merinos A.?. kolu olan Besni iplik fabrikas?nda çal??an 270 ki?iden toplanm??t?r. ölçe?in yap? geçerlili?i ve güvenilirli?i yap?lan istatistiki analizlerle test edilmi?ti...

In this article we present a study of the mixing time of a random walk on the largest component of a supercritical random graph, also known as the giant component. We identify local obstructions that slow down the randomwalk, when the average degree d is at mostO( √ ln n), proving that the mixing time in this case is ((ln n/d)2) asymptotically almost surely. As the average degree grows these be...