Alanine aminotransferase (ALT) elevation was occassionally observed during the treatment with combination peginterferon alpha plus ribavirin. Two forms of peginterferon are currently available as a standard of care with or without direct-acting antivirals against hepatitis C virus (HCV). Until the appearance of interferon-sparing regimen, peginterferon alpha plus ribavirin will play a central r...

Telomere length maintenance is essential for cellular immortalization, and thus tumorigenesis. Most human tumors and immortal cell lines maintain their telomeric DNA via the activity of a specialized reverse transcriptase, telomerase. Stabilization of telomeric repeat tracts may also be achieved through a telomerase-independent mechanism, referred to as alternative lengthening of telomeres (ALT...

In this work, an amperometric biosensor to determine ALT, which will be part of a system for simultaneous measurement AST and ALT their ratios, was developed. A platinum disk electrode used as the electrochemical transducer. To form bioselective element, mixture based on glutamate oxidase applied surface universal method measuring activity using developed proposed described. During study, optim...

retained by banks in their portfolios until they matured or were paid off. Securitization is a process by which mortgages (typically a large pool of mortgages) are used as collateral to issue securities, also known as mortgage-backed securities (MBS). Some mortgage securities are backed implicitly or explicitly by the U.S. government and are commonly called agency MBS. Such origination of mortg...

Liver disease can develop in chronic hepatitis B (CHB) patients with normal or mildly elevated alanine aminotransferase (ALT) who seldom undergo liver biopsy. We aimed to determine histologic characteristics of a large cohort of Chinese CHB patients undergoing liver biopsy and to evaluate the utility of ALT and HBV DNA values at the time of biopsy in predicting liver disease in this population....