In response to DNA damage, the ATM protein kinase activates signal transduction pathways essential for coordinating cell cycle progression with DNA repair. In the human disease ataxia-telangiectasia, mutation of the ATM gene results in multiple cellular defects, including enhanced sensitivity to ionizing radiation (IR). This phenotype highlights ATM as a potential target for novel inhibitors th...

High NaCl activates the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein (TonEBP/OREBP), resulting in increased transcription of several protective genes, including the glycine betaine/gamma-aminobutyric acid transporter (BGT1). High NaCl damages DNA, and DNA damage activates ataxia telangiectasia mutated (ATM) kinase through autophosphorylation on Ser-...

subjects of intense speculation by industry observers and potential users of the technologies , appear as if they may be ready to begin competing for their place in the networking sun. The demand for both technologies is being caused by the increasing adoption of Internet and intranet technology and the growing number of bandwidth-hungry applications. These factors make it necessary to move an ...

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role in the cellular response to DNA damage and in radiation resistance. Although much effort has focused on the relationship between ATM and other nuclear signal transducers, little is known about interactions between ATM and mitogenic signaling pathways. In this study, we show a novel relationship between ATM kinase and extracellular ...

This paper describes recent experiences with evaluating and implementing advanced internetwork communication protocols on top of ATM. First, performance results with conventional TCP/IP over ATM based on Digital Equipment’s Gigaswitch /ATM are reported. It becomes obvious that current protocols must be tuned specifically in order to exploit ATM performance. In order to address advanced quality ...

It is well documented that the eeective throughput of TCP can suuer on plain ATM networks. Several research eeorts have aimed at developing additions to ATM networks like Early Packet Discard that avoid TCP throughput degradation. This paper instead investigates improvements to TCP that allow it to perform well on ATM networks without switch-level enhancements, thus avoiding additional complexi...

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In certain hypoxic conditions, replication stress occurs in the absence of detectable DNA damage. H...

ATM (Asynchronous Transfer Mode) network is the core communication network of civil aviation aeronautical telecommunication network. So it is an urgent time to do scientific risk assessment for ATM network as soon as possible. According to threats and vulnerabilities existing in ATM network, which could bring bad influence to assets and missions of ATM network, even threaten the whole security ...

In response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here, we show that MRN-ATM also has critical functions in defending the cell against DNA viruses. We reveal temporally distinct responses to adenovirus genomes: a critical MRN-ATM DDR that must be inactivated by E1B-55K/E4-ORF3 viral oncoproteins and...

SEAN (Signaling Entity for ATM Networks) is freely distributed, object{oriented, extensible software for research and development in host ATM signaling. SEAN software is object{oriented and can be used both for simulation, experimentation, and operation. SEAN includes a complete source-level release of the host native ATM protocol stack, and implements the ATM User Network Interface, compliant ...