Psoriasis vulgaris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis. The human leukocyte antigen (HLA) class I allele, HLA-C*06:02, is the main psoriasis risk gene. Epidermal CD8(+) T cells are essential for psoriasis development. Functional implications of HLA-C*06:02 and mechanisms of lesional T cell activation in psoriasis, however, remained elus...

Prostacyclin (PGI2) plays an integral role in 02 mediation of pulmonary vasomotor tone in the fetus and newborn. We hypothesized that 02 modulates PG!2 synthesis in vitro in ovine fetal intrapulmonary arteries, with decreasing 02 causing attenuated synthesis. A decline in Po2 from 680 to 40 mmHg caused a 26% fall in basal PGI2 synthesis. PGI2 synthesis maximally stimulated by bradykinin, A23187...

Abstra ct. Hyperglycemia has been shown to induce arterial hypoxemia in the chronically catheterized fetal sheep. To investigate the mechanism behind this glucose-induced hypoxemia, eight pregnant ewes and their fetuses were studied. Fetal glucose infusion (1 1.9±0.6 mg glucose/kg per min) was associated with a doubling of the fetal plasma glucose concentration with concomitant elevation of the...

3 Magdalena Arévalo Turrubiarte ; Marie-Hélène Perruchot ; Laurence Finot ; Frédérique 4 Mayeur and Frédéric Dessauge 5 6 INRA, UMR1348 Pegase, F-35590 Saint-Gilles, France 7 Agrocampus Ouest, UMR1348 Pegase, F-35000 Rennes, France 8 Running head: Insight mammary epithelial cell line characterization 9 10 11 12 13 14 15 * Corresponding author: Frederic Dessauge, INRA, UMR1348 Pegase, Domaine de...

The Ras GTPases comprising three main isoforms H-, N- and K-Ras operate at the plasma membrane as molecular switches in essential signaling pathways. Active concentration of the minor phospholipid phosphatidylserine in the inner leaflet of the plasma membrane contributes to the electrostatic potential that is required for K-Ras anchoring to the plasma membrane. We recently observed that stauros...

Ultrahigh performance cooling is one of the important needs of many industries. However, low thermal conductivity is a primary limitation in developing energy-efficient heat transfer fluids that are required for cooling purposes. Nanofluids are engineered by suspending nanoparticles with average sizes below 100 nm in heat transfer fluids such as water, oil, diesel, ethylene glycol, etc. Innovat...

The opaque2 (02) modifier genes convert the soft endosperm of an 02 mutant to a hard, vitreous phenotype. The primary biochemical change associated with the expression of these genes is a twoto threefold increase in synthesis of the 27-kD y-zein storage protein. To investigate the mechanism of modifier gene activity, we examined the level of y-zein mRNA and protein synthesis during the early st...

Performance records on 41,184 Red Angus cattle were analyzed and estimates of parameters calculated for absolute growth rate, relative growth rate and restricted selection indices. Heritability estimates for birth weight, 205-d weight, 365-d weight and postweaning gain were .46 +/- .02, .39 +/- .02, .40 +/- .02 and .36 +/- .02, respectively. Heritability estimates for preweaning, postweaning an...

.........................................................................................ii List of Abbreviations...........................................................................01 List of Figure....................................................................................02 List of Table....................................................................................02 Chapt...