Neutrophils are key effectors of the host innate immune response against bacterial infection. Staphylococcus aureus is a preeminent human pathogen, with an ability to produce systemic infections even in previously healthy individuals, thereby reflecting a resistance to effective neutrophil clearance. The recent discovery of neutrophil extracellular traps (NETs) has opened a novel dimension in o...

Inward rectifier potassium (Kir) channels play important roles in the maintenance and control of cell excitability. Both intracellular trafficking and modulation of Kir channel activity are regulated by protein-protein interactions. We adopted a proteomics approach to identify proteins associated with Kir2 channels via the channel C-terminal PDZ binding motif. Detergent-solubilized rat brain an...

There is an upsurge in interest in the Markov model and also more general stationary ergodic stochastic distributions in theoretical computer science community recently, (e.g. see [Vitter,Krishnan,FOCS91], [Karlin,Philips,Raghavan,FOCS92] [Raghavan92]) for use of Markov models for on-line algorithms e.g., cashing and prefetching). Their results used the fact that compressible sources are predic...

The Diels-Alder reaction has often been used to construct polycyclic quinones from either benzoquinones or naphthoquinones.' This strategy has led to elegant syntheses of certain anthracyclines and also many other acetate-derived compounds. Several researchers, most notably Gesson and Brassard, have determined that the presence of a chlorine or bromine atom on the starting quinone framework per...

I recall sweet memories of Professor Hideo Tanaka during my academic research career on fuzzy theory, as well as elaborate on how his applied works have inspired me on my subsequent theoretical research concerning fuzzy modeling and decision-making. 2014 Published by Elsevier B.V. Fig. 1. A retirement party for M. Sugeno and H. Tanaka. At the very first International Fuzzy Systems Association (...

We describe a database of the single-particle optical properties cd marine microbial particles. This database includes representatives from five classes of particles: viruses (VIR), heterotrophic bacteria (BAC), cyanobacteria (CYA), small nanoplanktonic diatoms (DIA), and nanoplanktonic chlorophytes (CHLO). The optical properties of VIR, whose mean size is 0.07 pm, were determined from Mie scat...

-In previous work, we developed a method for active selection o f exemplars called AISB. Given a f ixed set o f exemplars, this method selects a concise subset for training, such that fitting the selected exemplars results in the entire set being f i t as well as desired. Our implementation o f A I S B incorporates a method for regulating network complexity, automatically adding exemplars and h...

-Extending our recent work, based on the ideas of the multi-grid iteration, we decrease the storage space for a smooth solution of a nonlinear PDF. and, furthermore, for any smooth function on a multi-dimensional grid and on discretization sets other than grids. A new approach to the numerical evaluation and storage of the solutions to a large class of linear part ial differential equations (PD...

•High concentration of black carbon (BC) can trigger a tipping point PBL development•With aerosol load above the point, maximum height decreases abruptly•The is caused by BC-induced decoupling vertical mixing zones•Reducing BC much more efficient to avoid than reducing other aerosols Air pollution major threat human health. Severe haze often an unexpected extremely shallow planetary boundary la...