Methods Bidirectional DNA Sequencing analysis of MEFV gene in all coding exons and exon-intron boundaries was performed in Turkish patients clinically pre-diagnosed as FMF consulted in Ege University School of Medicine between years 2009-2013 (n=8000) and in healthy control group individuals (n=250). For patients who were mutation negative in screened exons, exons 1, 4, 6, 7, 8, and 9 were also...

Introduction Cryopyrin-associated periodic syndrome (CAPS), clinically characterized by neutrophil-rich urticarial rash, is associated with missense mutations in NLRP3. NLRP3 is a pattern recognition receptor in the cytoplasm of cells and structurally related to plant resistance proteins, which detect pathogenor danger-associated signals, leading to programmed cell death and hyper response at t...

The purine metabolic enzymes adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are important in lymphocyte differentiation, and genetic deficiencies of either enzyme have been associated with hereditary immunodeficiency states. Both ADA and PNP activity were measured in null cell-enriched and T cell-enriched peripheral blood lymphocytes from 16 patients with the acquired immun...

Circadian changes in the susceptibility of adult individuals of three cricket species: field cricket (Gryllus campestris), house cricket (Acheta domesticus), and tropical house cricket (Gryllodes sigillatus) to insecticides belonging to the group of synthetic pyrethroids (Bulldock 025 EC) and oxadiazine (Steward 30 WG) were tested in 2007 and 2008. The assessment included the intoxication of su...

Immunotherapy has drastically improved the survival prospect for advanced melanoma. Unfortunately, these treatments often come with cutaneous side effects which may cause patient to discontinue or delay therapy. To understand mechanism of immunotoxicity in relation clinical presentation, we characterized symptom clusters by and histologic morphology, severity rating, transcriptional analyses pa...

This paper studies equilibrium refinements in signaling games through an examination of rationalizability in derived games obtained by replacing the equilibrium path with a sure outcome that yields the equilibrium payoff to ail players. The informed player chooses between the sure payoff and sending an out-of-equilibrium signal from the original game. Whether or not the strategy of choosing the...